Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis

M. Gilbert, Motomi (Tomi) Mori, E. S P Myhre

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study examined global hemodynamic responses to increasing concentrations of halothane and isoflurane in pigs with an acute critical coronary stenosis (CCS) on the left anterior descending coronary artery (LAD). The CCS was caused by graded infiltration of an hydraulic occluder to the point where no hyperemic response was observed following a 10 sec. total LAD-occlusion. A minute, piezoelectric epicardial Doppler probe applied without dissection was used to monitor the stenosis. Previously reported minimum alveolar concentrations (MAC) were used as endtidal concentrations ([Et]). The [Et] was increased stepwise until each animal died. Recordings obtained in this study were compared to recording obtained during similar stepwise increments of these anesthetics in pig preparations without CCS. Isoflurane had a significantly less depressant effect on global hemodynamics compared to halothane and caused death at higher MAC than halothane in either case. A critical LAD-stenosis caused no major changes in the general dose-response pattern of isoflurane but further aggravated the depression of cardiac output and stroke volume induced by increasing concentrations of halothane.

Original languageEnglish (US)
Pages (from-to)752-758
Number of pages7
JournalAnesthesia and Analgesia
Volume68
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Coronary Stenosis
Isoflurane
Halothane
Swine
Hemodynamics
Pathologic Constriction
Cardiac Volume
Cardiac Output
Stroke Volume
Anesthetics
Dissection
Coronary Vessels

Keywords

  • Anesthetics, volatile - halothane, isoflurane
  • Heart - coronary artery occlusion

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis. / Gilbert, M.; Mori, Motomi (Tomi); Myhre, E. S P.

In: Anesthesia and Analgesia, Vol. 68, No. 6, 1989, p. 752-758.

Research output: Contribution to journalArticle

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AB - This study examined global hemodynamic responses to increasing concentrations of halothane and isoflurane in pigs with an acute critical coronary stenosis (CCS) on the left anterior descending coronary artery (LAD). The CCS was caused by graded infiltration of an hydraulic occluder to the point where no hyperemic response was observed following a 10 sec. total LAD-occlusion. A minute, piezoelectric epicardial Doppler probe applied without dissection was used to monitor the stenosis. Previously reported minimum alveolar concentrations (MAC) were used as endtidal concentrations ([Et]). The [Et] was increased stepwise until each animal died. Recordings obtained in this study were compared to recording obtained during similar stepwise increments of these anesthetics in pig preparations without CCS. Isoflurane had a significantly less depressant effect on global hemodynamics compared to halothane and caused death at higher MAC than halothane in either case. A critical LAD-stenosis caused no major changes in the general dose-response pattern of isoflurane but further aggravated the depression of cardiac output and stroke volume induced by increasing concentrations of halothane.

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