Hemodynamic and regional blood flow response to milrinone in patients with severe congestive heart failure: A dose-ranging study

Patricia G. Fitzpatrick, Michael P. Cinquegrani, Arthur R. Vakiener, Judith G. Baggs, Theodore L. Biddle, Chang seng Liang, William B. Hood

    Research output: Contribution to journalArticle

    20 Scopus citations

    Abstract

    This study was undertaken to assess the hemodynamic efficacy, changes in regional blood flow, and safety of milrinone over a range of intravenous bolus injections (12.5 to 125 μg/kg), a continuous 18-hour infusion (0.2 to 0.7 μg/kg/min), and following oral administration. All eighteen patients with New York Heart Association class III or IV congestive heart failure demonstrated hemodynamic improvement following intravenous bolus therapy. Dose-related increases in cardiac index occurred, ranging from a 12 ± 6% increase following a 12.5 μg/kg bolus to a 37 ± 10% increase after 75 μg/kg. Pulmonary wedge pressure fell 17 ± 5% following 12.5 μg/kg and 28 ± 9% following 75 μg/kg. Little change was apparent during the continuous infusion except for a late increase in cardiac index, but similar changes occurred in response to a single oral dose. Forearm blood flow increased significantly after 3 hours in the two higher infusion groups, but there was no consistent change in hepatic blood flow. We conclude that hemodynamic parameters and forearm blood flow are improved in patients with severe congestive heart failure following intravenous and short-term oral milrinone therapy.

    Original languageEnglish (US)
    Pages (from-to)97-105
    Number of pages9
    JournalAmerican heart journal
    Volume114
    Issue number1 PART 1
    DOIs
    StatePublished - Jul 1987

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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