Hematologic Malignancies and Bone

Rebecca Silbermann, G. David Roodman

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Hematologic malignancies can have multiple direct and indirect effects on bone including pathologic fractures, bone pain, and hypercalcemia. This chapter discusses the pathophysiology of skeletal lesions in hematologic malignancies, with a focus on the current understanding of their associated bone disease, and includes brief discussions of radiologic imaging of skeletal lesions, pharmacologic treatments, and other hematologic malignancies that affect the bone. Multiple myeloma (MM) has the highest incidence of bone involvement among malignant diseases and is the second most common hematologic malignancy, accounting for approximately 15% of all hematologic malignancies. Magnetic resonance imaging (MRI) is effective in identification of lytic lesions and is indicated for staging in patients with solitary plasmacytoma of the bone. Currently, bisphosphonates remain the standard of care for MM-related bone disease. Adult T-cell leukemia/lymphoma (ATLL), non-Hodgkin's lymphoma (NHL), and Hodgkin's disease (HD) are the other hematologic malignancies discussed in the chapter.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Subtitle of host publicationEighth Edition
Number of pages8
ISBN (Electronic)9781118453926
ISBN (Print)9781118453889
StatePublished - Jul 19 2013
Externally publishedYes


  • Adult T-cell leukemia/lymphoma (ATLL)
  • Bisphosphonates
  • Bone
  • Hematologic malignancies
  • Magnetic resonance imaging (MRI)
  • Multiple myeloma (MM)
  • Non-Hodgkin's lymphoma (NHL)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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