Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States

Results from a retrospective chart review and cross-sectional survey

Caroline Schaefer, Rachael Mann, Alesia Sadosky, Shoshana Daniel, Bruce Parsons, Srinivas Nalamachu, Brett R. Stacey, Michael Tuchman, Alan Anschel, Edward Nieshoff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective:To characterize the burden of idiopathic painful peripheral neuropathy with small fiber involvement (idiopathic SFN) by pain severity in the US. Methods:One hundred previously diagnosed idiopathic SFN subjects were enrolled during routine office visits. Subjects completed a one-time questionnaire, and investigators reported clinical characteristics and healthcare resource use, based on 6 month retrospective chart review. Annualized direct and indirect costs were estimated. Results were stratified across pain severity groups. Results:Mean age was 63.5 years; 53.0% were female; 76.0% had moderate or severe pain. Most common comorbidities were sleep disturbance/insomnia (37.0%), anxiety (34.0%), and depressive symptoms (33.0%). Overall mean health status (0.59; -0.11-1.00 scale), physical and mental health (31.7 and 45.6, respectively, 0-100 scale), sleep index (45.1; 0-100 scale), and pain interference with function (5.0; 0-10 scale) differed by pain severity, with worse outcomes among those with greater pain (all p <0.002). 84.0% were prescribed 1 SFN medication. 16.0% were employed; mean overall work impairment was 36.9%. Annualized average adjusted direct and indirect costs per subject ($8055 and $13,733, respectively) differed by pain severity. Conclusions:Idiopathic SFN subjects with pain experience moderate or severe pain, which negatively impacts health status, function, and productivity, and leads to substantial direct and indirect costs.

Original languageEnglish (US)
Pages (from-to)394-407
Number of pages14
JournalJournal of Medical Economics
Volume17
Issue number6
DOIs
StatePublished - 2014

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Peripheral Nervous System Diseases
Health Status
Cross-Sectional Studies
Costs and Cost Analysis
Pain
Sleep
Painful Neuropathy
Office Visits
Sleep Initiation and Maintenance Disorders
Comorbidity
Mental Health
Anxiety
Research Personnel
Depression
Delivery of Health Care

Keywords

  • Burden
  • Costs
  • Function
  • Health status
  • Healthcare resource use
  • Idiopathic small fiber neuropathy
  • Neuropathic pain
  • Patient-reported outcomes
  • Productivity

ASJC Scopus subject areas

  • Health Policy
  • Medicine(all)

Cite this

Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States : Results from a retrospective chart review and cross-sectional survey. / Schaefer, Caroline; Mann, Rachael; Sadosky, Alesia; Daniel, Shoshana; Parsons, Bruce; Nalamachu, Srinivas; Stacey, Brett R.; Tuchman, Michael; Anschel, Alan; Nieshoff, Edward.

In: Journal of Medical Economics, Vol. 17, No. 6, 2014, p. 394-407.

Research output: Contribution to journalArticle

Schaefer, Caroline ; Mann, Rachael ; Sadosky, Alesia ; Daniel, Shoshana ; Parsons, Bruce ; Nalamachu, Srinivas ; Stacey, Brett R. ; Tuchman, Michael ; Anschel, Alan ; Nieshoff, Edward. / Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States : Results from a retrospective chart review and cross-sectional survey. In: Journal of Medical Economics. 2014 ; Vol. 17, No. 6. pp. 394-407.
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AU - Sadosky, Alesia

AU - Daniel, Shoshana

AU - Parsons, Bruce

AU - Nalamachu, Srinivas

AU - Stacey, Brett R.

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AU - Anschel, Alan

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N2 - Objective:To characterize the burden of idiopathic painful peripheral neuropathy with small fiber involvement (idiopathic SFN) by pain severity in the US. Methods:One hundred previously diagnosed idiopathic SFN subjects were enrolled during routine office visits. Subjects completed a one-time questionnaire, and investigators reported clinical characteristics and healthcare resource use, based on 6 month retrospective chart review. Annualized direct and indirect costs were estimated. Results were stratified across pain severity groups. Results:Mean age was 63.5 years; 53.0% were female; 76.0% had moderate or severe pain. Most common comorbidities were sleep disturbance/insomnia (37.0%), anxiety (34.0%), and depressive symptoms (33.0%). Overall mean health status (0.59; -0.11-1.00 scale), physical and mental health (31.7 and 45.6, respectively, 0-100 scale), sleep index (45.1; 0-100 scale), and pain interference with function (5.0; 0-10 scale) differed by pain severity, with worse outcomes among those with greater pain (all p <0.002). 84.0% were prescribed 1 SFN medication. 16.0% were employed; mean overall work impairment was 36.9%. Annualized average adjusted direct and indirect costs per subject ($8055 and $13,733, respectively) differed by pain severity. Conclusions:Idiopathic SFN subjects with pain experience moderate or severe pain, which negatively impacts health status, function, and productivity, and leads to substantial direct and indirect costs.

AB - Objective:To characterize the burden of idiopathic painful peripheral neuropathy with small fiber involvement (idiopathic SFN) by pain severity in the US. Methods:One hundred previously diagnosed idiopathic SFN subjects were enrolled during routine office visits. Subjects completed a one-time questionnaire, and investigators reported clinical characteristics and healthcare resource use, based on 6 month retrospective chart review. Annualized direct and indirect costs were estimated. Results were stratified across pain severity groups. Results:Mean age was 63.5 years; 53.0% were female; 76.0% had moderate or severe pain. Most common comorbidities were sleep disturbance/insomnia (37.0%), anxiety (34.0%), and depressive symptoms (33.0%). Overall mean health status (0.59; -0.11-1.00 scale), physical and mental health (31.7 and 45.6, respectively, 0-100 scale), sleep index (45.1; 0-100 scale), and pain interference with function (5.0; 0-10 scale) differed by pain severity, with worse outcomes among those with greater pain (all p <0.002). 84.0% were prescribed 1 SFN medication. 16.0% were employed; mean overall work impairment was 36.9%. Annualized average adjusted direct and indirect costs per subject ($8055 and $13,733, respectively) differed by pain severity. Conclusions:Idiopathic SFN subjects with pain experience moderate or severe pain, which negatively impacts health status, function, and productivity, and leads to substantial direct and indirect costs.

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