Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

John J. Chen; J. A. Hollenbach; E. A. Trachtenberg; J. J. Just; M. Carrington; K. S. Rønningen; A. Begovich; M. C. King; S. McWeeney; S. J. Mack; H. A. Erlich; G. Thomson

doi:10.1034/j.1399-0039.1999.540601.x

Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

John J. Chen, J. A. Hollenbach, E. A. Trachtenberg, J. J. Just, M. Carrington, K. S. Rønningen, A. Begovich, M. C. King, S. McWeeney, S. J. Mack, H. A. Erlich, G. Thomson

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.

Original language	English (US)
Pages (from-to)	533-542
Number of pages	10
Journal	Tissue Antigens
Volume	54
Issue number	6
DOIs	https://doi.org/10.1034/j.1399-0039.1999.540601.x
State	Published - 1999
Externally published	Yes

Keywords

Exact test
HLA
Hardy-Weinberg proportions
Individual test
Population genetics

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1034/j.1399-0039.1999.540601.x

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Chen, J. J., Hollenbach, J. A., Trachtenberg, E. A., Just, J. J., Carrington, M., Rønningen, K. S., Begovich, A., King, M. C., McWeeney, S., Mack, S. J., Erlich, H. A., & Thomson, G. (1999). Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups. Tissue Antigens, 54(6), 533-542. https://doi.org/10.1034/j.1399-0039.1999.540601.x

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abstract = "Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.",

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AU - Just, J. J.

AU - Carrington, M.

AU - Rønningen, K. S.

AU - Begovich, A.

AU - King, M. C.

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AU - Erlich, H. A.

AU - Thomson, G.

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AB - Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.

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Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

Abstract

Keywords

ASJC Scopus subject areas

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