Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

John J. Chen, J. A. Hollenbach, E. A. Trachtenberg, J. J. Just, M. Carrington, K. S. Rønningen, A. Begovich, M. C. King, Shannon McWeeney, S. J. Mack, H. A. Erlich, G. Thomson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Testing the fit of population data to Hardy-Weinberg proportions is crucial in the validation of many current approaches in population genetic studies. In this paper, we tested fit to Hardy-Weinberg proportions using exact approaches for both the overall and individual heterozygote genotype data of four HLA Class II loci: DRB1, DQA1, DQB1, and DPB1, from 26 human populations. Eighty of 99 overall tests fit the Hardy-Weinberg expectation (73% for DRB1, 89% for DQA1, 81% for DQB1 and 81% for DPB1). Deviations from Hardy-Weinberg proportions were both locus and group specific. Although we could not rule out other mechanisms at work, the individual test results indicated that the departure was possibly partly due to recent admixture. Evidence for selection and other sources of deviation are also discussed.

Original languageEnglish (US)
Pages (from-to)533-542
Number of pages10
JournalTissue Antigens
Volume54
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

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Ethnic Groups
Population Genetics
Heterozygote
Population
Genotype

Keywords

  • Exact test
  • Hardy-Weinberg proportions
  • HLA
  • Individual test
  • Population genetics

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Chen, J. J., Hollenbach, J. A., Trachtenberg, E. A., Just, J. J., Carrington, M., Rønningen, K. S., ... Thomson, G. (1999). Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups. Tissue Antigens, 54(6), 533-542. https://doi.org/10.1034/j.1399-0039.1999.540601.x

Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups. / Chen, John J.; Hollenbach, J. A.; Trachtenberg, E. A.; Just, J. J.; Carrington, M.; Rønningen, K. S.; Begovich, A.; King, M. C.; McWeeney, Shannon; Mack, S. J.; Erlich, H. A.; Thomson, G.

In: Tissue Antigens, Vol. 54, No. 6, 1999, p. 533-542.

Research output: Contribution to journalArticle

Chen, JJ, Hollenbach, JA, Trachtenberg, EA, Just, JJ, Carrington, M, Rønningen, KS, Begovich, A, King, MC, McWeeney, S, Mack, SJ, Erlich, HA & Thomson, G 1999, 'Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups', Tissue Antigens, vol. 54, no. 6, pp. 533-542. https://doi.org/10.1034/j.1399-0039.1999.540601.x
Chen JJ, Hollenbach JA, Trachtenberg EA, Just JJ, Carrington M, Rønningen KS et al. Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups. Tissue Antigens. 1999;54(6):533-542. https://doi.org/10.1034/j.1399-0039.1999.540601.x
Chen, John J. ; Hollenbach, J. A. ; Trachtenberg, E. A. ; Just, J. J. ; Carrington, M. ; Rønningen, K. S. ; Begovich, A. ; King, M. C. ; McWeeney, Shannon ; Mack, S. J. ; Erlich, H. A. ; Thomson, G. / Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups. In: Tissue Antigens. 1999 ; Vol. 54, No. 6. pp. 533-542.
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