Handling-induced enhancement of alcohol's acute physiological effects

Joanna Peris; Christopher L. Cunningham

doi:10.1016/0024-3205(86)90313-9

Handling-induced enhancement of alcohol's acute physiological effects

Joanna Peris, Christopher L. Cunningham

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.

Original language	English (US)
Pages (from-to)	273-279
Number of pages	7
Journal	Life Sciences
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(86)90313-9
State	Published - Jan 20 1986

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(86)90313-9

Cite this

@article{c2f55f0dc449459b978936a166843d95,

title = "Handling-induced enhancement of alcohol's acute physiological effects",

abstract = "A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.",

author = "Joanna Peris and Cunningham, {Christopher L.}",

note = "Funding Information: Some of these findings were presented at the 14th Annual Meeting of the Neuroscience Society. We thank Ann Kosobud for her assistance with the blood and brain ethanol assays. We also thank our colleagues who offered comments on earlier versions of this ms, J. P. was supported by NHLBI Training Grant HL07332 and is now at the Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262. This research was supported in part by NIAAA Grant AA06161 and Biomedical Research Support Grant S07-RR05412.",

year = "1986",

month = jan,

day = "20",

doi = "10.1016/0024-3205(86)90313-9",

language = "English (US)",

volume = "38",

pages = "273--279",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Handling-induced enhancement of alcohol's acute physiological effects

AU - Peris, Joanna

AU - Cunningham, Christopher L.

N1 - Funding Information: Some of these findings were presented at the 14th Annual Meeting of the Neuroscience Society. We thank Ann Kosobud for her assistance with the blood and brain ethanol assays. We also thank our colleagues who offered comments on earlier versions of this ms, J. P. was supported by NHLBI Training Grant HL07332 and is now at the Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262. This research was supported in part by NIAAA Grant AA06161 and Biomedical Research Support Grant S07-RR05412.

PY - 1986/1/20

Y1 - 1986/1/20

N2 - A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.

AB - A mild stressor (handling) exacerbated the acute effects of ethanol on heart rate and body temperature in rats. Although the tachycardia produced by the combination of ethanol and handling appeared to be due to a simple summation of the separate tachycardic effects of each condition, the thermal change represented a nonadditive combination of the separate effects. Specifically, although handling alone produced hyperthermia, it enhanced the hypothermia induced by ethanol. Blood and brain levels of ethanol were not altered by handling. Stress-induced enhancement of critical responses to ethanol may have important implications for the development of tolerance to and dependence on alcohol.

UR - http://www.scopus.com/inward/record.url?scp=0022591805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022591805&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(86)90313-9

DO - 10.1016/0024-3205(86)90313-9

M3 - Article

C2 - 3941595

AN - SCOPUS:0022591805

SN - 0024-3205

VL - 38

SP - 273

EP - 279

JO - Life Sciences

JF - Life Sciences

IS - 3

ER -

Handling-induced enhancement of alcohol's acute physiological effects

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this