Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the us multi-society task force on colorectal cancer

Francis M. Giardiello, John I. Allen, Jennifer E. Axilbund, C. Richard Boland, Carol A. Burke, Randall W. Burt, James M. Church, Jason A. Dominitz, David A. Johnson, Tonya Kaltenbach, Theodore R. Levin, David A. Lieberman, Douglas J. Robertson, Sapna Syngal, Douglas K. Rex

Research output: Contribution to journalArticle

193 Scopus citations

Abstract

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3-6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

Original languageEnglish (US)
Pages (from-to)502-526
Number of pages25
JournalGastroenterology
Volume147
Issue number2
DOIs
StatePublished - Aug 2014

Keywords

  • Colorectal Cancer
  • Genetic Testing
  • Lynch Syndrome

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Giardiello, F. M., Allen, J. I., Axilbund, J. E., Boland, C. R., Burke, C. A., Burt, R. W., Church, J. M., Dominitz, J. A., Johnson, D. A., Kaltenbach, T., Levin, T. R., Lieberman, D. A., Robertson, D. J., Syngal, S., & Rex, D. K. (2014). Guidelines on genetic evaluation and management of lynch syndrome: A consensus statement by the us multi-society task force on colorectal cancer. Gastroenterology, 147(2), 502-526. https://doi.org/10.1053/j.gastro.2014.04.001