TY - JOUR
T1 - Growth hormone response to apomorphine and diagnosis
T2 - A comparison of three diagnostic systems
AU - Hirschowitz, Jack
AU - Zemlan, Frank P.
AU - Hitzemann, Robert J.
AU - Fleischmann, Roberta L.
AU - Garver, David L.
PY - 1986/5
Y1 - 1986/5
N2 - Our study takes a further look at the apomorphine test in the psychoses and affective disorders, with special reference to the use of different diagnostic systems. Patients meeting Research Diagnostic Criteria (RDC) for schizophrenia, schizoaffective disorder, or manic disorder were included. In addition to the RDC, diagnosis was also made using the DSM-III and ICD-9. All patients underwent an evaluation of peak GH response to apomorphine administration. The results show that RDC and ICD-9 are similar, in that for both systems, a high GH response correlates with a schizoaffective disorder and distinguishes those patients significantly from manic patients. The DMS-III brings in some new dimensions, in that schizophreniform disorder (6-month cut-off) is distinguished from schizophrenia. In addition, patients with affective symptoms and mood-incongruent psychoses are more closely related to schizophreniform disorder than to classical manic disorder.
AB - Our study takes a further look at the apomorphine test in the psychoses and affective disorders, with special reference to the use of different diagnostic systems. Patients meeting Research Diagnostic Criteria (RDC) for schizophrenia, schizoaffective disorder, or manic disorder were included. In addition to the RDC, diagnosis was also made using the DSM-III and ICD-9. All patients underwent an evaluation of peak GH response to apomorphine administration. The results show that RDC and ICD-9 are similar, in that for both systems, a high GH response correlates with a schizoaffective disorder and distinguishes those patients significantly from manic patients. The DMS-III brings in some new dimensions, in that schizophreniform disorder (6-month cut-off) is distinguished from schizophrenia. In addition, patients with affective symptoms and mood-incongruent psychoses are more closely related to schizophreniform disorder than to classical manic disorder.
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U2 - 10.1016/0006-3223(86)90186-1
DO - 10.1016/0006-3223(86)90186-1
M3 - Article
C2 - 3697435
AN - SCOPUS:0022919263
SN - 0006-3223
VL - 21
SP - 445
EP - 454
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5-6
ER -