Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

Sunwen Chou; Gail I. Marousek; Laura C. Van Wechel; Shaobing Li; Adriana Weinberg

doi:10.1128/AAC.00736-07

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

Sunwen Chou, Gail I. Marousek, Laura C. Van Wechel, Shaobing Li, Adriana Weinberg

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

Original language	English (US)
Pages (from-to)	4160-4162
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00736-07
State	Published - Nov 2007

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.",

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AU - Chou, Sunwen

AU - Marousek, Gail I.

AU - Van Wechel, Laura C.

AU - Li, Shaobing

AU - Weinberg, Adriana

PY - 2007/11

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AB - Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

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Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

Abstract

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