Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

Sunwen Chou, Gail I. Marousek, Laura C. Van Wechel, Shaobing Li, Adriana Weinberg

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

Original languageEnglish (US)
Pages (from-to)4160-4162
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number11
DOIs
StatePublished - Nov 2007

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DNA Polymerase III
Cytomegalovirus
Drug Resistance
Ganciclovir
Phenotype
Mutation
Growth
Foscarnet
Bacterial Artificial Chromosomes
Clone Cells

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. / Chou, Sunwen; Marousek, Gail I.; Van Wechel, Laura C.; Li, Shaobing; Weinberg, Adriana.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 11, 11.2007, p. 4160-4162.

Research output: Contribution to journalArticle

Chou, Sunwen ; Marousek, Gail I. ; Van Wechel, Laura C. ; Li, Shaobing ; Weinberg, Adriana. / Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 11. pp. 4160-4162.
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