GPVI and integrin αIIbβ3 signaling in platelets

S. P. Watson, J. M. Auger, O. J.T. McCarty, A. C. Pearce

Research output: Contribution to journalArticle

281 Scopus citations

Abstract

This review summarizes recent developments in our understanding of the molecular basis of platelet activation by two distinct types of surface receptor, the immunoglobulin GPVI, and the integrin αIIbβ3 (also known as GPIIbIIIa). These two classes of receptor signal through similar yet distinct tyrosine kinase-based signaling cascades leading to activation of phospholipase Cγ2. The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed.

Original languageEnglish (US)
Pages (from-to)1752-1762
Number of pages11
JournalJournal of Thrombosis and Haemostasis
Volume3
Issue number8
DOIs
StatePublished - Dec 9 2005

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Keywords

  • Collagen
  • GPVI
  • Integrin
  • Src kinases
  • Syk
  • Tyrosine kinases

ASJC Scopus subject areas

  • Hematology

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