Goodness-of-Fit and Local Identifiability of a Receptor-Binding Radiopharmacokinetic System

David R. Vera, Paul O. Scheibe, Kenneth Krohn, Walter L. Trudeau, Robert C. Stadalnik

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A four-state nonlinear model describing a radiopharmacokinetic system for a hepatic receptor-binding radiopharmaceutical, [99mTc]-gaIactosyl-neoglycoalbumin (TcNGA), was tested for goodness-of-fit and local identifiability using scanning data from nine healthy subjects and seven patients with severe liver disease. Based on standard deviations of liver and heart imaging data at equilibria as a measure of observational error, the reduced chi-square ranged from 0.5 to 2.6. Values above 1.2 occurred when the subject moved during the 30 min study. Relative standard errors for each parameter were: TcNGA-receptor forward binding rate constant kb, 13–54%; extra-hepatic plasma volume Ve, 0.8–15.0%; hepatic plasma volume Vh, 0.2–6.5%; hepatic plasma flow F, 54 → > 1000%; and receptor concentration [R]o, 0.3–13%. The highest standard errors ocurred when the amount of TcNGA injected exceeded the total amount of receptor. Therefore, when TcNGA functional imaging was performed without excess patient motion and receptor saturation, the kinetic model provided data fits of low systematic error and yielded high precision estimates of receptor concentration and forward binding rate constant. In summary, optimal performance of the kinetic model occurred when the amount of injected TcNGA resulted in the nonlinear operation of the pharmacokinetic system.

Original languageEnglish (US)
Pages (from-to)356-367
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Volume39
Issue number4
DOIs
StatePublished - 1992
Externally publishedYes

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Liver
Rate constants
Plasmas
Imaging techniques
Plasma flow
Kinetics
Pharmacokinetics
Systematic errors
Scanning

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Goodness-of-Fit and Local Identifiability of a Receptor-Binding Radiopharmacokinetic System. / Vera, David R.; Scheibe, Paul O.; Krohn, Kenneth; Trudeau, Walter L.; Stadalnik, Robert C.

In: IEEE Transactions on Biomedical Engineering, Vol. 39, No. 4, 1992, p. 356-367.

Research output: Contribution to journalArticle

Vera, David R. ; Scheibe, Paul O. ; Krohn, Kenneth ; Trudeau, Walter L. ; Stadalnik, Robert C. / Goodness-of-Fit and Local Identifiability of a Receptor-Binding Radiopharmacokinetic System. In: IEEE Transactions on Biomedical Engineering. 1992 ; Vol. 39, No. 4. pp. 356-367.
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