Glomerulonephritis With Masked Monotypic Immunoglobulin Deposits and Concurrent Lymphomatous Infiltration

Isaac E. Lloyd, Mazdak Khalighi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kidney injury can be a complication of hematopoietic neoplasia by both direct and indirect mechanisms. Virtually all lymphomas and plasma cell dyscrasias can show kidney involvement, including parenchymal infiltration and by secondary injury. Recently, a unique form of glomerulonephritis with masked monotypic immunoglobulin deposits has been reported, which shows frequent association with hematopoietic neoplasia and a propensity for progressive kidney disease. In many instances, these cases are likely diagnosed as glomerulonephritis with dominant C3 due to the absence of immunoglobulin staining by routine immunofluorescence microscopy. The patient reported here showed lymphomatous infiltration on kidney biopsy and mesangial proliferative glomerulonephritis with dominant staining for C3 without immunoglobulins on initial immunofluorescence; however, monotypic immunoglobulin G κ light chain was revealed after additional immunofluorescence staining was performed on the paraffin-embedded tissue. This patient's case highlights the evolving state of kidney biopsy interpretation and the expanding spectrum of kidney disease in the setting of hematopoietic neoplasia.

Original languageEnglish (US)
Pages (from-to)640-644
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Fingerprint

Glomerulonephritis
Immunoglobulins
Kidney
Kidney Diseases
Staining and Labeling
Fluorescent Antibody Technique
Immunoglobulin Light Chains
Biopsy
Neoplasms
Paraproteinemias
Wounds and Injuries
Fluorescence Microscopy
Paraffin
Lymphoma
Immunoglobulin G

Keywords

  • antigen retrieval
  • Glomerulonephritis
  • hematopoietic neoplasia
  • IgGκ
  • kidney biopsy
  • lymphomatous infiltration
  • masked deposits
  • proteinase predigestion
  • renal infiltration

ASJC Scopus subject areas

  • Nephrology

Cite this

Glomerulonephritis With Masked Monotypic Immunoglobulin Deposits and Concurrent Lymphomatous Infiltration. / Lloyd, Isaac E.; Khalighi, Mazdak.

In: American Journal of Kidney Diseases, Vol. 68, No. 4, 01.10.2016, p. 640-644.

Research output: Contribution to journalArticle

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