Ghrelin

T. D. Müller; R. Nogueiras; M. L. Andermann; Z. B. Andrews; S. D. Anker; J. Argente; R. L. Batterham; S. C. Benoit; C. Y. Bowers; F. Broglio; F. F. Casanueva; D. D'Alessio; I. Depoortere; A. Geliebter; E. Ghigo; P. A. Cole; M. Cowley; D. E. Cummings; A. Dagher; S. Diano; S. L. Dickson; C. Diéguez; R. Granata; H. J. Grill; K. Grove; K. M. Habegger; K. Heppner; M. L. Heiman; L. Holsen; B. Holst; A. Inui; J. O. Jansson; H. Kirchner; M. Korbonits; B. Laferrère; C. W. LeRoux; M. Lopez; S. Morin; M. Nakazato; R. Nass; D. Perez-Tilve; P. T. Pfluger; T. W. Schwartz; R. J. Seeley; M. Sleeman; Y. Sun; L. Sussel; J. Tong; M. O. Thorner; A. J. van der Lely; L. H.T. van der Ploeg; J. M. Zigman; M. Kojima; K. Kangawa; R. G. Smith; T. Horvath; M. H. Tschöp

doi:10.1016/j.molmet.2015.03.005

Ghrelin

T. D. Müller, R. Nogueiras, M. L. Andermann, Z. B. Andrews, S. D. Anker, J. Argente, R. L. Batterham, S. C. Benoit, C. Y. Bowers, F. Broglio, F. F. Casanueva, D. D'Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P. A. Cole, M. Cowley, D. E. Cummings, A. Dagher, S. DianoS. L. Dickson, C. Diéguez, R. Granata, H. J. Grill, K. Grove, K. M. Habegger, K. Heppner, M. L. Heiman, L. Holsen, B. Holst, A. Inui, J. O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C. W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P. T. Pfluger, T. W. Schwartz, R. J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M. O. Thorner, A. J. van der Lely, L. H.T. van der Ploeg, J. M. Zigman, M. Kojima, K. Kangawa, R. G. Smith, T. Horvath, M. H. Tschöp

Research output: Contribution to journal › Review article › peer-review

789 Scopus citations

Abstract

The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original language	English (US)
Pages (from-to)	437-460
Number of pages	24
Journal	Molecular Metabolism
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/j.molmet.2015.03.005
State	Published - Jun 1 2015

Keywords

Ghrelin
Growth hormone segretagogue receptor

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molmet.2015.03.005

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Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., ... Tschöp, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

Müller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Diéguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO, van der Lely, AJ, van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, T & Tschöp, MH 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

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title = "Ghrelin",

abstract = "The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",

keywords = "Ghrelin, Growth hormone segretagogue receptor",

author = "M{\"u}ller, {T. D.} and R. Nogueiras and Andermann, {M. L.} and Andrews, {Z. B.} and Anker, {S. D.} and J. Argente and Batterham, {R. L.} and Benoit, {S. C.} and Bowers, {C. Y.} and F. Broglio and Casanueva, {F. F.} and D. D'Alessio and I. Depoortere and A. Geliebter and E. Ghigo and Cole, {P. A.} and M. Cowley and Cummings, {D. E.} and A. Dagher and S. Diano and Dickson, {S. L.} and C. Di{\'e}guez and R. Granata and Grill, {H. J.} and K. Grove and Habegger, {K. M.} and K. Heppner and Heiman, {M. L.} and L. Holsen and B. Holst and A. Inui and Jansson, {J. O.} and H. Kirchner and M. Korbonits and B. Laferr{\`e}re and LeRoux, {C. W.} and M. Lopez and S. Morin and M. Nakazato and R. Nass and D. Perez-Tilve and Pfluger, {P. T.} and Schwartz, {T. W.} and Seeley, {R. J.} and M. Sleeman and Y. Sun and L. Sussel and J. Tong and Thorner, {M. O.} and {van der Lely}, {A. J.} and {van der Ploeg}, {L. H.T.} and Zigman, {J. M.} and M. Kojima and K. Kangawa and Smith, {R. G.} and T. Horvath and Tsch{\"o}p, {M. H.}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.molmet.2015.03.005",

language = "English (US)",

volume = "4",

pages = "437--460",

journal = "Molecular Metabolism",

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T1 - Ghrelin

AU - Müller, T. D.

AU - Nogueiras, R.

AU - Andermann, M. L.

AU - Andrews, Z. B.

AU - Anker, S. D.

AU - Argente, J.

AU - Batterham, R. L.

AU - Benoit, S. C.

AU - Bowers, C. Y.

AU - Broglio, F.

AU - Casanueva, F. F.

AU - D'Alessio, D.

AU - Depoortere, I.

AU - Geliebter, A.

AU - Ghigo, E.

AU - Cole, P. A.

AU - Cowley, M.

AU - Cummings, D. E.

AU - Dagher, A.

AU - Diano, S.

AU - Dickson, S. L.

AU - Diéguez, C.

AU - Granata, R.

AU - Grill, H. J.

AU - Grove, K.

AU - Habegger, K. M.

AU - Heppner, K.

AU - Heiman, M. L.

AU - Holsen, L.

AU - Holst, B.

AU - Inui, A.

AU - Jansson, J. O.

AU - Kirchner, H.

AU - Korbonits, M.

AU - Laferrère, B.

AU - LeRoux, C. W.

AU - Lopez, M.

AU - Morin, S.

AU - Nakazato, M.

AU - Nass, R.

AU - Perez-Tilve, D.

AU - Pfluger, P. T.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Sleeman, M.

AU - Sun, Y.

AU - Sussel, L.

AU - Tong, J.

AU - Thorner, M. O.

AU - van der Lely, A. J.

AU - van der Ploeg, L. H.T.

AU - Zigman, J. M.

AU - Kojima, M.

AU - Kangawa, K.

AU - Smith, R. G.

AU - Horvath, T.

AU - Tschöp, M. H.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

AB - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

KW - Ghrelin

KW - Growth hormone segretagogue receptor

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U2 - 10.1016/j.molmet.2015.03.005

DO - 10.1016/j.molmet.2015.03.005

M3 - Review article

AN - SCOPUS:84929964936

SN - 2212-8778

VL - 4

SP - 437

EP - 460

JO - Molecular Metabolism

JF - Molecular Metabolism

IS - 6

ER -

Ghrelin

Abstract

Keywords

ASJC Scopus subject areas

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