Genomic instability and the role of radiation quality

M. A. Kadhim, M. A. Hill, Stephen Moore

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Genomic instability (GI) is a hallmark of tumorigenic progression and is observed as delayed genetic damage in the progeny of irradiated and unirradiated bystander cells. The expression of GI can be influenced by genotype, cell type and radiation quality. While several studies have demonstrated the induction of GI by high and low-linear energy transfer (LET) radiation, our work on human and mouse primary cell systems has shown LET-dependent differences in the induction and expression of GI. These differences might be attributed to differences in radiation track structure, dose rate, contribution of bystander cells and radiation dose. This paper reviews the role of radiation quality in the induction of GI and describe the possible mechanisms underlining the observed differences between radiation types on its induction. The experimental results presented suggest that dose might be the most significant factor in determining induction of GI after low-LET radiation.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalRadiation Protection Dosimetry
Volume122
Issue number1-4
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Genomic Instability
Radiation
induction
Linear Energy Transfer
linear energy transfer (LET)
radiation
Energy transfer
Dosimetry
cells
dosage
progeny
progressions
mice
Genotype
damage

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Genomic instability and the role of radiation quality. / Kadhim, M. A.; Hill, M. A.; Moore, Stephen.

In: Radiation Protection Dosimetry, Vol. 122, No. 1-4, 12.2006, p. 221-227.

Research output: Contribution to journalArticle

Kadhim, M. A. ; Hill, M. A. ; Moore, Stephen. / Genomic instability and the role of radiation quality. In: Radiation Protection Dosimetry. 2006 ; Vol. 122, No. 1-4. pp. 221-227.
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