Genome amplification of chromosome 20 in breast cancer

J. Graeme Hodgson, Kwang-Yung Chin, Colin Collins, Joe Gray

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Recurrent gain and amplification of the long arm of chromosome 20 (20q) has been observed in a wide variety of cancers. This suggests that a gene or genes encoded on 20q play important roles in contributing to the cancer phenotype when overexpressed. In the quest to discover cancer genes, this region of the genome has been exhaustively studied, and the results demonstrate remarkable complexity. Multiple regions of low and high-level 20q copy number gain correlate with poor clinical prognosis and appear to contribute to the cancer phenotype, especially aspects of immortalization, genome instability, apoptosis, and increased proliferation. Gene discovery efforts have revealed a number of interesting candidate genes on chromosome 20 that may contribute to oncogenic progression. The study of 20q serves as a model for positional cloning enthusiasts, demonstrating the path typically taken when moving from initial discovery of an important genomic abnormality to identification of genes likely to be significant players in disease progression. This review will summarize approximately a decade of study on 20q and is structured as moving from an introduction to the techniques used in 20q analyses, to the details of 20q genomic complexity and its involvement with cancer, and finally to a detailed gene-specific look at this region.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalBreast Cancer Research and Treatment
Volume78
Issue number3
DOIs
StatePublished - Apr 2003
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 20
Genome
Breast Neoplasms
Genes
Neoplasms
Phenotype
Genomic Instability
Neoplasm Genes
Genetic Association Studies
Disease Progression
Organism Cloning
Apoptosis

Keywords

  • 20q
  • Amplification
  • Array CGH
  • Breast cancer
  • Gene discovery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Genome amplification of chromosome 20 in breast cancer. / Hodgson, J. Graeme; Chin, Kwang-Yung; Collins, Colin; Gray, Joe.

In: Breast Cancer Research and Treatment, Vol. 78, No. 3, 04.2003, p. 337-345.

Research output: Contribution to journalArticle

Hodgson, J. Graeme ; Chin, Kwang-Yung ; Collins, Colin ; Gray, Joe. / Genome amplification of chromosome 20 in breast cancer. In: Breast Cancer Research and Treatment. 2003 ; Vol. 78, No. 3. pp. 337-345.
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