Genitourinary functions of Hoxa13 and Hoxd13

Virginia Scott, Emily Morgan, H. Scott Stadler

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In the United States, Japan, United Kingdom, and Sweden, birth defects affecting the growth and development of the genitourinary (GU) regions are becoming increasingly prevalent, with incidences ranging as high as 1 in 125 live births. To understand the basis for these malformations, scientists have begun to examine the function of developmental genes in GU tissues. At the forefront of these investigations are studies examining the role of the 5′ HOX proteins during the formation of the GU region. In this report we discuss what is known about HOXA13 and HOXD13 function during GU development, highlighting some of the cellular and molecular mechanisms controlled by these proteins during the GU formation. Finally, the translational benefits of identifying HOX target genes are discussed; first to explain the prevalence of some GU defects as well as a mechanism to facilitate their prevention in the birth population.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalJournal of Biochemistry
Volume137
Issue number6
DOIs
StatePublished - Jun 2005

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Genes
Developmental Genes
Defects
Live Birth
Growth and Development
Sweden
Japan
Proteins
Parturition
Tissue
Incidence
Population
United Kingdom

Keywords

  • External genitalia
  • Hand foot genital syndrome
  • Hox
  • Hypospadias
  • Synpolydactyly

ASJC Scopus subject areas

  • Biochemistry

Cite this

Genitourinary functions of Hoxa13 and Hoxd13. / Scott, Virginia; Morgan, Emily; Stadler, H. Scott.

In: Journal of Biochemistry, Vol. 137, No. 6, 06.2005, p. 671-676.

Research output: Contribution to journalArticle

Scott, Virginia ; Morgan, Emily ; Stadler, H. Scott. / Genitourinary functions of Hoxa13 and Hoxd13. In: Journal of Biochemistry. 2005 ; Vol. 137, No. 6. pp. 671-676.
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