Genetics of sanguinis-Group Streptococci in Health and Disease

Angela Nobbs, Jens Kreth

Research output: Contribution to journalArticle

Abstract

With the application of increasingly advanced "omics" technologies to the study of our resident oral microbiota, the presence of a defined, health-associated microbial community has been recognized. Within this community, sanguinis-group streptococci, comprising the closely related Streptococcus sanguinis and Streptococcus gordonii, together with Streptococcus parasanguinis, often predominate. Their ubiquitous and abundant nature reflects the evolution of these bacteria as highly effective colonizers of the oral cavity. Through interactions with host tissues and other microbes, and the capacity to readily adapt to prevailing environmental conditions, sanguinis-group streptococci are able to shape accretion of the oral plaque biofilm and promote development of a microbial community that exists in harmony with its host. Nonetheless, upon gaining access to the blood stream, those very same colonization capabilities can confer upon sanguinis-group streptococci the ability to promote systemic disease. This article focuses on the role of sanguinis-group streptococci as the commensurate commensals, highlighting those aspects of their biology that enable the coordination of health-associated biofilm development. This includes the molecular mechanisms, both synergistic and antagonistic, that underpin adhesion to substrata, intercellular communication, and polymicrobial community formation. As our knowledge of these processes advances, so will the opportunities to exploit this understanding for future development of novel strategies to control oral and extraoral disease.

Original languageEnglish (US)
JournalMicrobiology spectrum
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

health and disease
Streptococcus
biofilm
microbial community
commensal
advanced technology
Health
adhesion
cavity
colonization
blood
accretion
environmental conditions
communication
Biofilms
bacterium
Mouth Diseases
Streptococcus gordonii
Microbiota
Mouth

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

Cite this

Genetics of sanguinis-Group Streptococci in Health and Disease. / Nobbs, Angela; Kreth, Jens.

In: Microbiology spectrum, Vol. 7, No. 1, 01.01.2019.

Research output: Contribution to journalArticle

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