Genetics of Personality Disorders: Perspectives From Personality and Psychopathology Research

Joel T. Nigg, H. Hill Goldsmith

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Although the field is young, studies pertinent to genetic hypotheses have accumulated for several personality disorders. Genetic links to personality disorders from the domains of normal personality and Axis I disorders are reviewed. Evidence of a link to schizophrenia is clearest for schizotypal and less conclusive for paranoid and schizoid personality disorders. A genetic association between borderline personality disorder and affective disorders has not been clearly supported, but there may be a subtype genetically linked to affective disorders. Evidence of genetic influence is mixed for obsessive-compulsive personality disorder. In general, greater attention to dimensional phenotypic measures and multivariate designs can yield more definitive answers regarding the correct subtyping and probable etiology of personality disorders.

Original languageEnglish (US)
Pages (from-to)346-380
Number of pages35
JournalPsychological Bulletin
Issue number3
StatePublished - May 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychology(all)


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