Genetics of mouse behavior: Interactions with laboratory environment

John C. Crabbe, Douglas Wahlsten, Bruce C. Dudek

Research output: Contribution to journalArticle

1228 Scopus citations

Abstract

Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.

Original languageEnglish (US)
Pages (from-to)1670-1672
Number of pages3
JournalScience
Volume284
Issue number5420
DOIs
StatePublished - Jun 4 1999

ASJC Scopus subject areas

  • General

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