Genetic screen reveals link between the maternal effect sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in caenorhabditis elegans

Qiuli Wu, Xiou Cao, Dong Yan, Dayong Wang, Alejandro Aballay

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosainduced neurodegeneration, we identified mes-1, which encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line. We showed that sterile but not fertile mes-1 animals were resistant to neurodegeneration induced by P. aeruginosa infection. Similar results were observed using animals carrying a mutation in the maternal effect gene PGL-1, which is required for postembryonic germ line development, and the germ line-deficient strains glp-1 and glp-4. Additional studies indicated that the FOXO transcription factor DAF-16 is required for resistance to P. aeruginosa-induced neurodegeneration in germ line-deficient strains. Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. Elegans that are controlled by the germ line in a cell-nonautonomous manner.

Original languageEnglish (US)
Pages (from-to)29231-29239
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number49
DOIs
StatePublished - Dec 4 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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