Genetic screen reveals link between the maternal effect sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in caenorhabditis elegans

Qiuli Wu, Xiou Cao, Dong Yan, Dayong Wang, Alejandro Aballay

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosainduced neurodegeneration, we identified mes-1, which encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line. We showed that sterile but not fertile mes-1 animals were resistant to neurodegeneration induced by P. aeruginosa infection. Similar results were observed using animals carrying a mutation in the maternal effect gene PGL-1, which is required for postembryonic germ line development, and the germ line-deficient strains glp-1 and glp-4. Additional studies indicated that the FOXO transcription factor DAF-16 is required for resistance to P. aeruginosa-induced neurodegeneration in germ line-deficient strains. Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. Elegans that are controlled by the germ line in a cell-nonautonomous manner.

Original languageEnglish (US)
Pages (from-to)29231-29239
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number49
DOIs
StatePublished - Dec 4 2015
Externally publishedYes

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Caenorhabditis elegans
Germ Cells
Pseudomonas aeruginosa
Animals
Pseudomonas Infections
Genes
Neurodegenerative diseases
Receptor Protein-Tyrosine Kinases
Transcription Factors
Cells
Proteins
Neurodegenerative Diseases
Cell Division
Maternal Inheritance
Phenotype
Mutation
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Genetic screen reveals link between the maternal effect sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in caenorhabditis elegans. / Wu, Qiuli; Cao, Xiou; Yan, Dong; Wang, Dayong; Aballay, Alejandro.

In: Journal of Biological Chemistry, Vol. 290, No. 49, 04.12.2015, p. 29231-29239.

Research output: Contribution to journalArticle

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