TY - JOUR
T1 - Genetic polymorphisms associated with the risk of concussion in 1056 college athletes
T2 - A multicentre prospective cohort study
AU - Terrell, Thomas Roland
AU - Abramson, Ruth
AU - Barth, Jeffery T.
AU - Bennett, Ellen
AU - Cantu, Robert C.
AU - Sloane, Richard
AU - Laskowitz, Daniel T.
AU - Erlanger, David M.
AU - McKeag, Douglas
AU - Nichols, Gregory
AU - Valentine, Verle
AU - Galloway, Leslie
N1 - Funding Information:
Funding Grant funding was provided by the National Operating Committee on Standards for Athletic Equipment (NOCSAE), American Medical Society of Sports Medicine (AMSSM), and Physicians Medical Education and Research Foundation of the University of Tennessee Medical Center (PMERF). The opinions expressed by the authors are not those of these organizations, but are rather our own.
Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
PY - 2018/2
Y1 - 2018/2
N2 - Background/aim To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser 53 Pro, MAPT/tau Hist 47 Tyr, IL-6572 G/C and IL-6R Asp 358 Ala with the risk of concussion in college athletes. Methods A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. Results The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. Conclusions IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.
AB - Background/aim To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser 53 Pro, MAPT/tau Hist 47 Tyr, IL-6572 G/C and IL-6R Asp 358 Ala with the risk of concussion in college athletes. Methods A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. Results The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. Conclusions IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.
KW - APOE4
KW - IL-6 gene
KW - genotype
KW - sport
KW - traumatic brain injury
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U2 - 10.1136/bjsports-2016-097419
DO - 10.1136/bjsports-2016-097419
M3 - Article
C2 - 28918391
AN - SCOPUS:85041842124
SN - 0306-3674
VL - 52
SP - 192
EP - 198
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 3
ER -