Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

Thomas Roland Terrell, Ruth Abramson, Jeffery T. Barth, Ellen Bennett, Robert C. Cantu, Richard Sloane, Daniel T. Laskowitz, David M. Erlanger, Douglas McKeag, Gregory Nichols, Verle Valentine, Leslie Galloway

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.

METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.

RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.

CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalBritish Journal of Sports Medicine
Volume52
Issue number3
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Fingerprint

Genetic Polymorphisms
Athletes
Cohort Studies
Prospective Studies
Microtubule-Associated Proteins
Football
Wrestling
Baseball
Basketball
Soccer
African Americans
Exons
Logistic Models
Alleles
Regression Analysis

Keywords

  • APOE4
  • genotype
  • IL-6 gene
  • sport
  • traumatic brain injury

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Genetic polymorphisms associated with the risk of concussion in 1056 college athletes : a multicentre prospective cohort study. / Terrell, Thomas Roland; Abramson, Ruth; Barth, Jeffery T.; Bennett, Ellen; Cantu, Robert C.; Sloane, Richard; Laskowitz, Daniel T.; Erlanger, David M.; McKeag, Douglas; Nichols, Gregory; Valentine, Verle; Galloway, Leslie.

In: British Journal of Sports Medicine, Vol. 52, No. 3, 01.02.2018, p. 192-198.

Research output: Contribution to journalArticle

Terrell, TR, Abramson, R, Barth, JT, Bennett, E, Cantu, RC, Sloane, R, Laskowitz, DT, Erlanger, DM, McKeag, D, Nichols, G, Valentine, V & Galloway, L 2018, 'Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study', British Journal of Sports Medicine, vol. 52, no. 3, pp. 192-198. https://doi.org/10.1136/bjsports-2016-097419
Terrell, Thomas Roland ; Abramson, Ruth ; Barth, Jeffery T. ; Bennett, Ellen ; Cantu, Robert C. ; Sloane, Richard ; Laskowitz, Daniel T. ; Erlanger, David M. ; McKeag, Douglas ; Nichols, Gregory ; Valentine, Verle ; Galloway, Leslie. / Genetic polymorphisms associated with the risk of concussion in 1056 college athletes : a multicentre prospective cohort study. In: British Journal of Sports Medicine. 2018 ; Vol. 52, No. 3. pp. 192-198.
@article{db81665aadf24035813d06d7439f6efc,
title = "Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study",
abstract = "BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3{\%} male, 59.4{\%} Caucasian, 35.0{\%} African-American, 5.6{\%} other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1{\%} prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95{\%} CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95{\%} CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40{\%} lower risk.",
keywords = "APOE4, genotype, IL-6 gene, sport, traumatic brain injury",
author = "Terrell, {Thomas Roland} and Ruth Abramson and Barth, {Jeffery T.} and Ellen Bennett and Cantu, {Robert C.} and Richard Sloane and Laskowitz, {Daniel T.} and Erlanger, {David M.} and Douglas McKeag and Gregory Nichols and Verle Valentine and Leslie Galloway",
year = "2018",
month = "2",
day = "1",
doi = "10.1136/bjsports-2016-097419",
language = "English (US)",
volume = "52",
pages = "192--198",
journal = "British Journal of Sports Medicine",
issn = "0306-3674",
publisher = "BMJ Publishing Group",
number = "3",

}

TY - JOUR

T1 - Genetic polymorphisms associated with the risk of concussion in 1056 college athletes

T2 - a multicentre prospective cohort study

AU - Terrell, Thomas Roland

AU - Abramson, Ruth

AU - Barth, Jeffery T.

AU - Bennett, Ellen

AU - Cantu, Robert C.

AU - Sloane, Richard

AU - Laskowitz, Daniel T.

AU - Erlanger, David M.

AU - McKeag, Douglas

AU - Nichols, Gregory

AU - Valentine, Verle

AU - Galloway, Leslie

PY - 2018/2/1

Y1 - 2018/2/1

N2 - BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

AB - BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

KW - APOE4

KW - genotype

KW - IL-6 gene

KW - sport

KW - traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85041842124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041842124&partnerID=8YFLogxK

U2 - 10.1136/bjsports-2016-097419

DO - 10.1136/bjsports-2016-097419

M3 - Article

C2 - 28918391

AN - SCOPUS:85041842124

VL - 52

SP - 192

EP - 198

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 3

ER -