Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

Thomas Roland Terrell, Ruth Abramson, Jeffery T. Barth, Ellen Bennett, Robert C. Cantu, Richard Sloane, Daniel T. Laskowitz, David M. Erlanger, Douglas McKeag, Gregory Nichols, Verle Valentine, Leslie Galloway

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.

METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.

RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.

CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalBritish Journal of Sports Medicine
Volume52
Issue number3
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Keywords

  • APOE4
  • genotype
  • IL-6 gene
  • sport
  • traumatic brain injury

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Terrell, T. R., Abramson, R., Barth, J. T., Bennett, E., Cantu, R. C., Sloane, R., Laskowitz, D. T., Erlanger, D. M., McKeag, D., Nichols, G., Valentine, V., & Galloway, L. (2018). Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study. British Journal of Sports Medicine, 52(3), 192-198. https://doi.org/10.1136/bjsports-2016-097419