Genetic investigation into the differential risk of atrial fibrillation among black and white individuals

Jason D. Roberts, Donglei Hu, Susan R. Heckbert, Alvaro Alonso, Thomas Dewland, Eric Vittinghoff, Yongmei Liu, Bruce M. Psaty, Jeffrey E. Olgin, Jared W. Magnani, Scott Huntsman, Esteban G. Burchard, Dan E. Arking, Kirsten Bibbins-Domingo, Tamara B. Harris, Marco V. Perez, Elad Ziv, Gregory M. Marcus

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

IMPORTANCE White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. OBJECTIVES To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon. DESIGN, SETTING, AND PARTICIPANTS Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the Health, Aging, and Body Composition (Health ABC) (n = 1015) study. In all 3 studies, race was self-identified. Cox proportional hazards regression models and the proportion of treatment effectmethod were used to determine the impact of 9 AF-risk SNPs among participants from CHS and the ARIC study. The present study began July 1, 2012, and was completed in 2015. MAIN OUTCOMES AND MEASURES Incident AF systematically ascertained using clinic visit electrocardiograms, hospital discharge diagnosis codes, death certificates, and Medicare claims data. RESULTS A single SNP, rs10824026 (chromosome 10: Position 73661450), was found to significantly mediate the higher risk for AF in white participants compared with black participants in CHS (11.4%; 95%CI, 2.9%-29.9%) and ARIC (31.7%; 95%CI, 16.0%-53.0%). Admixture mapping was performed in ameta-analysis of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015). No loci that reached the prespecified statistical threshold for genome-wide significance were identified. CONCLUSIONS AND RELEVANCE The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1. No additional genetic variants accounting for a significant portion of the differential racial risk of AF were identified with genome-wide admixture mapping, suggesting that additional genetic or environmental influences beyond single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals and black individuals.

Original languageEnglish (US)
Pages (from-to)442-450
Number of pages9
JournalJAMA Cardiology
Volume1
Issue number4
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

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Atrial Fibrillation
Single Nucleotide Polymorphism
Atherosclerosis
Health
Genome
Body Composition
hydroquinone
Chromosomes, Human, Pair 10
Death Certificates
Ambulatory Care
Medicare
Proportional Hazards Models
Electrocardiography
Cohort Studies
Chromosomes
Outcome Assessment (Health Care)
Gene Expression

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Genetic investigation into the differential risk of atrial fibrillation among black and white individuals. / Roberts, Jason D.; Hu, Donglei; Heckbert, Susan R.; Alonso, Alvaro; Dewland, Thomas; Vittinghoff, Eric; Liu, Yongmei; Psaty, Bruce M.; Olgin, Jeffrey E.; Magnani, Jared W.; Huntsman, Scott; Burchard, Esteban G.; Arking, Dan E.; Bibbins-Domingo, Kirsten; Harris, Tamara B.; Perez, Marco V.; Ziv, Elad; Marcus, Gregory M.

In: JAMA Cardiology, Vol. 1, No. 4, 01.07.2016, p. 442-450.

Research output: Contribution to journalArticle

Roberts, JD, Hu, D, Heckbert, SR, Alonso, A, Dewland, T, Vittinghoff, E, Liu, Y, Psaty, BM, Olgin, JE, Magnani, JW, Huntsman, S, Burchard, EG, Arking, DE, Bibbins-Domingo, K, Harris, TB, Perez, MV, Ziv, E & Marcus, GM 2016, 'Genetic investigation into the differential risk of atrial fibrillation among black and white individuals', JAMA Cardiology, vol. 1, no. 4, pp. 442-450. https://doi.org/10.1001/jamacardio.2016.1185
Roberts, Jason D. ; Hu, Donglei ; Heckbert, Susan R. ; Alonso, Alvaro ; Dewland, Thomas ; Vittinghoff, Eric ; Liu, Yongmei ; Psaty, Bruce M. ; Olgin, Jeffrey E. ; Magnani, Jared W. ; Huntsman, Scott ; Burchard, Esteban G. ; Arking, Dan E. ; Bibbins-Domingo, Kirsten ; Harris, Tamara B. ; Perez, Marco V. ; Ziv, Elad ; Marcus, Gregory M. / Genetic investigation into the differential risk of atrial fibrillation among black and white individuals. In: JAMA Cardiology. 2016 ; Vol. 1, No. 4. pp. 442-450.
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abstract = "IMPORTANCE White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. OBJECTIVES To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon. DESIGN, SETTING, AND PARTICIPANTS Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the Health, Aging, and Body Composition (Health ABC) (n = 1015) study. In all 3 studies, race was self-identified. Cox proportional hazards regression models and the proportion of treatment effectmethod were used to determine the impact of 9 AF-risk SNPs among participants from CHS and the ARIC study. The present study began July 1, 2012, and was completed in 2015. MAIN OUTCOMES AND MEASURES Incident AF systematically ascertained using clinic visit electrocardiograms, hospital discharge diagnosis codes, death certificates, and Medicare claims data. RESULTS A single SNP, rs10824026 (chromosome 10: Position 73661450), was found to significantly mediate the higher risk for AF in white participants compared with black participants in CHS (11.4{\%}; 95{\%}CI, 2.9{\%}-29.9{\%}) and ARIC (31.7{\%}; 95{\%}CI, 16.0{\%}-53.0{\%}). Admixture mapping was performed in ameta-analysis of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015). No loci that reached the prespecified statistical threshold for genome-wide significance were identified. CONCLUSIONS AND RELEVANCE The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1. No additional genetic variants accounting for a significant portion of the differential racial risk of AF were identified with genome-wide admixture mapping, suggesting that additional genetic or environmental influences beyond single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals and black individuals.",
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T1 - Genetic investigation into the differential risk of atrial fibrillation among black and white individuals

AU - Roberts, Jason D.

AU - Hu, Donglei

AU - Heckbert, Susan R.

AU - Alonso, Alvaro

AU - Dewland, Thomas

AU - Vittinghoff, Eric

AU - Liu, Yongmei

AU - Psaty, Bruce M.

AU - Olgin, Jeffrey E.

AU - Magnani, Jared W.

AU - Huntsman, Scott

AU - Burchard, Esteban G.

AU - Arking, Dan E.

AU - Bibbins-Domingo, Kirsten

AU - Harris, Tamara B.

AU - Perez, Marco V.

AU - Ziv, Elad

AU - Marcus, Gregory M.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - IMPORTANCE White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. OBJECTIVES To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon. DESIGN, SETTING, AND PARTICIPANTS Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the Health, Aging, and Body Composition (Health ABC) (n = 1015) study. In all 3 studies, race was self-identified. Cox proportional hazards regression models and the proportion of treatment effectmethod were used to determine the impact of 9 AF-risk SNPs among participants from CHS and the ARIC study. The present study began July 1, 2012, and was completed in 2015. MAIN OUTCOMES AND MEASURES Incident AF systematically ascertained using clinic visit electrocardiograms, hospital discharge diagnosis codes, death certificates, and Medicare claims data. RESULTS A single SNP, rs10824026 (chromosome 10: Position 73661450), was found to significantly mediate the higher risk for AF in white participants compared with black participants in CHS (11.4%; 95%CI, 2.9%-29.9%) and ARIC (31.7%; 95%CI, 16.0%-53.0%). Admixture mapping was performed in ameta-analysis of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015). No loci that reached the prespecified statistical threshold for genome-wide significance were identified. CONCLUSIONS AND RELEVANCE The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1. No additional genetic variants accounting for a significant portion of the differential racial risk of AF were identified with genome-wide admixture mapping, suggesting that additional genetic or environmental influences beyond single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals and black individuals.

AB - IMPORTANCE White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors. OBJECTIVES To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon. DESIGN, SETTING, AND PARTICIPANTS Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the Health, Aging, and Body Composition (Health ABC) (n = 1015) study. In all 3 studies, race was self-identified. Cox proportional hazards regression models and the proportion of treatment effectmethod were used to determine the impact of 9 AF-risk SNPs among participants from CHS and the ARIC study. The present study began July 1, 2012, and was completed in 2015. MAIN OUTCOMES AND MEASURES Incident AF systematically ascertained using clinic visit electrocardiograms, hospital discharge diagnosis codes, death certificates, and Medicare claims data. RESULTS A single SNP, rs10824026 (chromosome 10: Position 73661450), was found to significantly mediate the higher risk for AF in white participants compared with black participants in CHS (11.4%; 95%CI, 2.9%-29.9%) and ARIC (31.7%; 95%CI, 16.0%-53.0%). Admixture mapping was performed in ameta-analysis of black participants within CHS (n = 811), ARIC (n = 3112), and Health ABC (n = 1015). No loci that reached the prespecified statistical threshold for genome-wide significance were identified. CONCLUSIONS AND RELEVANCE The rs10824026 SNP on chromosome 10q22 mediates a modest proportion of the increased risk of AF among white individuals compared with black individuals, potentially through an effect on gene expression levels of MYOZ1. No additional genetic variants accounting for a significant portion of the differential racial risk of AF were identified with genome-wide admixture mapping, suggesting that additional genetic or environmental influences beyond single SNPs in isolation may account for the paradoxical racial risk of AF among white individuals and black individuals.

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