Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian

Eric W. Schmidt, Sebastian Sudek, Margo G. Haygood

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Didemnid family ascidians commonly harbor obligate cyanobacterial symbionts, Prochloron spp., which have been proposed to biosynthesize cyclic peptides. Here, it is shown that Prochloron spp. do indeed contain genes for nonribosomal peptide biosynthesis, although genes for cyclic peptide biosynthesis have not yet been characterized. A peptide synthetase-containing open reading frame of unknown function was cloned from the Prochloron symbionts of some didemnid ascidians, but not from others. These data indicate that Prochloron spp. have variable secondary metabolic potential.

Original languageEnglish (US)
Pages (from-to)1341-1345
Number of pages5
JournalJournal of Natural Products
Volume67
Issue number8
DOIs
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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