Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian

Eric W. Schmidt, Sebastian Sudek, Margo Haygood

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Didemnid family ascidians commonly harbor obligate cyanobacterial symbionts, Prochloron spp., which have been proposed to biosynthesize cyclic peptides. Here, it is shown that Prochloron spp. do indeed contain genes for nonribosomal peptide biosynthesis, although genes for cyclic peptide biosynthesis have not yet been characterized. A peptide synthetase-containing open reading frame of unknown function was cloned from the Prochloron symbionts of some didemnid ascidians, but not from others. These data indicate that Prochloron spp. have variable secondary metabolic potential.

Original languageEnglish (US)
Pages (from-to)1341-1345
Number of pages5
JournalJournal of Natural Products
Volume67
Issue number8
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Prochloron
Urochordata
Cyclic Peptides
Biosynthesis
Ascidiacea
symbionts
Genes
Peptide Synthases
cyclic peptides
Ports and harbors
Nucleic Acid-Independent Peptide Biosynthesis
Peptide Biosynthesis
biosynthesis
peptides
Peptides
ligases
Open Reading Frames
open reading frames
genes

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian. / Schmidt, Eric W.; Sudek, Sebastian; Haygood, Margo.

In: Journal of Natural Products, Vol. 67, No. 8, 08.2004, p. 1341-1345.

Research output: Contribution to journalArticle

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