Genetic dissection of myelinated axons in zebrafish

Kelly Monk, William S. Talbot

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

In the vertebrate nervous system, the myelin sheath allows for rapid and efficient conduction of action potentials along axons. Despite the essential function of myelin, many questions remain unanswered about the mechanisms that govern the development of myelinated axons. The fundamental properties of myelin are widely shared among vertebrates, and the zebrafish has emerged as a powerful system to study myelination in vivo. This review will highlight recent advances from genetic screens in zebrafish, including the discovery of the role of kif1b in mRNA localization in myelinating oligodendrocytes.

Original languageEnglish (US)
Pages (from-to)486-490
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume19
Issue number5
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Zebrafish
Myelin Sheath
Axons
Dissection
Vertebrates
Oligodendroglia
Nervous System
Action Potentials
Messenger RNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Genetic dissection of myelinated axons in zebrafish. / Monk, Kelly; Talbot, William S.

In: Current Opinion in Neurobiology, Vol. 19, No. 5, 01.10.2009, p. 486-490.

Research output: Contribution to journalReview article

Monk, Kelly ; Talbot, William S. / Genetic dissection of myelinated axons in zebrafish. In: Current Opinion in Neurobiology. 2009 ; Vol. 19, No. 5. pp. 486-490.
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