Genetic dissection of myelinated axons in zebrafish

Kelly R. Monk, William S. Talbot

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

In the vertebrate nervous system, the myelin sheath allows for rapid and efficient conduction of action potentials along axons. Despite the essential function of myelin, many questions remain unanswered about the mechanisms that govern the development of myelinated axons. The fundamental properties of myelin are widely shared among vertebrates, and the zebrafish has emerged as a powerful system to study myelination in vivo. This review will highlight recent advances from genetic screens in zebrafish, including the discovery of the role of kif1b in mRNA localization in myelinating oligodendrocytes.

Original languageEnglish (US)
Pages (from-to)486-490
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume19
Issue number5
DOIs
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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