Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion

Tamara Phillips, Julie Broadbent, Sue Burkhart-Kasch, Carly Henderson, Charlotte D. Wenger, Carrie McMullin, Carrie S. McKinnon, Christopher Cunningham

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Short-term selective breeding created mouse lines divergent for ethanol drinking (high drinking short-term selected line [STDRHI], low drinking [STDRLO]) or ethanol-induced conditioned taste aversion (CTA; high [HTA], low [LTA]). Compared with STDRLO, STDRHI mice consumed more saccharin and less quinine, exhibited greater ethanol-induced conditioned place preference (CPP), and showed reduced ethanol stimulation and sensitization under some conditions; a line difference in ethanol-induced CTA was not consistently found. Compared with LTA, HTA mice consumed less ethanol but were similar in saccharin consumption, sensitivity to ethanol-induced CPP, and ethanol-induced locomotor stimulation and sensitization. These data suggest that ethanol drinking is genetically associated with several reward- and aversion-related traits. The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2.

Original languageEnglish (US)
Pages (from-to)892-910
Number of pages19
JournalBehavioral Neuroscience
Volume119
Issue number4
DOIs
StatePublished - Aug 2005

Fingerprint

Reward
Drinking
Ethanol
Phenotype
Saccharin
Quinine

Keywords

  • Alcohol
  • Conditioned place preference
  • Locomotor stimulation
  • Saccharin preference
  • Sensitization

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. / Phillips, Tamara; Broadbent, Julie; Burkhart-Kasch, Sue; Henderson, Carly; Wenger, Charlotte D.; McMullin, Carrie; McKinnon, Carrie S.; Cunningham, Christopher.

In: Behavioral Neuroscience, Vol. 119, No. 4, 08.2005, p. 892-910.

Research output: Contribution to journalArticle

Phillips, Tamara ; Broadbent, Julie ; Burkhart-Kasch, Sue ; Henderson, Carly ; Wenger, Charlotte D. ; McMullin, Carrie ; McKinnon, Carrie S. ; Cunningham, Christopher. / Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion. In: Behavioral Neuroscience. 2005 ; Vol. 119, No. 4. pp. 892-910.
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