Abstract
This review presents data on genetic and functional analysis of some of the HIV-1 genes derived from HIV-1 infected individuals from north India (Delhi, Punjab and Chandigarh). We found evidence of novel B/C recombinants in HIV-1 LTR region showing relatedness to China/Mynmar with 3 copies of Nfκb sites; B/C/D mosaic genomes for HIV-1 Vpr and novel B/C Tat. We reported appearance of a complex recombinant form CRF_02AG of HIV-1 envelope sequences which is predominantly found in Central/Western Africa. Also one Indian HIV-1 envelope subtype C sequence suggested exclusive CXCR4 co-receptor usage. This extensive recombination, which is observed in about 10 per cent HIV-1 infected individuals in the Vpr genes, resulted in remarkably altered functions when compared with prototype subtype B Vpr. The Vpu C was found to be more potent in causing apoptosis when compared with Vpu B when analyzed for subG1 DNA content. The functional implications of these changes as well as in other genes of HIV-1 are discussed in detail with possible implications for subtype-specific pathogenesis highlighted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 769-778 |
| Number of pages | 10 |
| Journal | Indian Journal of Medical Research |
| Volume | 134 |
| Issue number | 12 |
| State | Published - Dec 2011 |
Keywords
- HIV-1 genetic variants
- HIV-1 recombinants
- HIV-1 subtypes
- India
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology