Genetic and molecular mapping of the Hmt region of mouse

S. Richards, M. Bucan, K. Brorson, M. C. Kiefer, S. W. Hunt, H. Lehrach, K. Fischer Lindahl

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We have mapped a new region of the mouse major histocompatibility complex (MHC) that contains the nuclear gene, Hmt, for the maternally transmitted antigen, Mta. The Hmt region of chromosome 17 lies between a recombinational breakpoint distal to Tla and another proximal to Tpx-1, thus including Pgk-2. A novel MHC class I gene fragment, R4B2, was cloned and mapped to this region as was another new class I gene, Thy19.4. Both lie proximal to Pgk-2, within the distal inversion in t-haplotypes. The presence of several other MHC class I genes in the Hmt region is predicted from analysis of the recombinants that define the region.

Original languageEnglish (US)
Pages (from-to)3749-3757
Number of pages9
JournalEMBO Journal
Volume8
Issue number12
DOIs
StatePublished - Jan 1 1989

Keywords

  • MHC class I genes
  • genome organization
  • maternally transmitted antigen (Mta)
  • mouse chromosome 17
  • t-complex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Richards, S., Bucan, M., Brorson, K., Kiefer, M. C., Hunt, S. W., Lehrach, H., & Fischer Lindahl, K. (1989). Genetic and molecular mapping of the Hmt region of mouse. EMBO Journal, 8(12), 3749-3757. https://doi.org/10.1002/j.1460-2075.1989.tb08551.x