Genetic alterations distinguish different types of ovarian tumors

M. Pieretti, C. Cavalieri, P. S. Conway, H. H. Gallion, D. E. Powell, Mitchell Turker

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Seventy-four sporadic ovarian tumors were studied for loss of heterozygosity (LOH) and microsatellite instability (MI) with 20 polymorphic markers on chromosome 17 and at least 1 marker on every other chromosome. Additionally, activation of the K-ras oncogene was examined through mutation analysis of codon 12. A majority of the tumors analyzed were low grade and/or of the mucinous histologic type. A negative correlation between LOH on chromosome 17 and K-ras activation was observed, with the former alteration present in the majority of high grade serous and endometrioid tumors and the latter most commonly found in the mucinous and low malignant potential (LMP) tumors. In 60% of cases where LOH on chromosome 17 was present, it was observed at all informative markers, indicating chromosome loss. In these cases, frequent events of LOH were observed on the other chromosomes. When confined events of LOH were observed on chromosome 17, fewer events of LOH were observed on the other chromosomes. In the absence of LOH on chromosome 17, LOH on other chromosomes was rare. K-ras activation was most commonly observed in tumors with no LOH events. Two endometrioid tumors and 2 mucinous tumors demonstrated MI. Our data support the involvement of different molecular pathways in the development of different types of ovarian tumors.

Original languageEnglish (US)
Pages (from-to)434-440
Number of pages7
JournalInternational Journal of Cancer
Volume64
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

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Loss of Heterozygosity
Chromosomes, Human, Pair 17
Neoplasms
Chromosomes
Microsatellite Instability
ras Genes
Genetic Markers
Codon
Mutation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pieretti, M., Cavalieri, C., Conway, P. S., Gallion, H. H., Powell, D. E., & Turker, M. (1995). Genetic alterations distinguish different types of ovarian tumors. International Journal of Cancer, 64(6), 434-440. https://doi.org/10.1002/ijc.2910640614

Genetic alterations distinguish different types of ovarian tumors. / Pieretti, M.; Cavalieri, C.; Conway, P. S.; Gallion, H. H.; Powell, D. E.; Turker, Mitchell.

In: International Journal of Cancer, Vol. 64, No. 6, 1995, p. 434-440.

Research output: Contribution to journalArticle

Pieretti, M, Cavalieri, C, Conway, PS, Gallion, HH, Powell, DE & Turker, M 1995, 'Genetic alterations distinguish different types of ovarian tumors', International Journal of Cancer, vol. 64, no. 6, pp. 434-440. https://doi.org/10.1002/ijc.2910640614
Pieretti, M. ; Cavalieri, C. ; Conway, P. S. ; Gallion, H. H. ; Powell, D. E. ; Turker, Mitchell. / Genetic alterations distinguish different types of ovarian tumors. In: International Journal of Cancer. 1995 ; Vol. 64, No. 6. pp. 434-440.
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