Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)

Michael Litt; D. LaMorticella; C. T. Bond; J. P. Adelman

doi:10.1159/000015415

Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)

Michael Litt, D. LaMorticella, C. T. Bond, J. P. Adelman

Vollum Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.

Original language	English (US)
Pages (from-to)	70-73
Number of pages	4
Journal	Cytogenetics and Cell Genetics
Volume	86
Issue number	1
DOIs	https://doi.org/10.1159/000015415
State	Published - 1999

ASJC Scopus subject areas

Genetics
Cell Biology

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abstract = "Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.",

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AU - Adelman, J. P.

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AB - Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.

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Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1)

Abstract

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