Gender, sex steroids, and cerebral ischemic pathobiology

Ines Koerner, S. J. Murphy, P. D. Hurn

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Biological sex is an important genetic determinant of outcome from cerebral ischemia and clinical stroke. Emerging data suggest that sex, as well as reproductive steroids, shapes ischemic cell death in brain. Female sex steroids, the estrogens and progesterone, provide robust neuroprotection in a variety of experimental settings and strongly contribute to sex-specific responses to ischemia. The purpose of this chapter is: (1) to review the importance of biological sex to ischemic outcome and mechanisms of brain injury, (2) to evaluate the role of female sex steroids as endogenous or exogenous ischemic neuroprotectants, and (3) to review most likely mechanisms by which female sex steroids act to interrupt ischemic cell death pathways.

Original languageEnglish (US)
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System
PublisherSpringer US
Pages185-207
Number of pages23
ISBN (Print)9780387303468
DOIs
StatePublished - 2007

Fingerprint

Steroids
Cell death
Brain
Neuroprotective Agents
Cell Death
Progesterone
Estrogens
Brain Ischemia
Brain Injuries
Ischemia
Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Koerner, I., Murphy, S. J., & Hurn, P. D. (2007). Gender, sex steroids, and cerebral ischemic pathobiology. In Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System (pp. 185-207). Springer US. https://doi.org/10.1007/978-0-387-30383-3_11

Gender, sex steroids, and cerebral ischemic pathobiology. / Koerner, Ines; Murphy, S. J.; Hurn, P. D.

Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, 2007. p. 185-207.

Research output: Chapter in Book/Report/Conference proceedingChapter

Koerner, I, Murphy, SJ & Hurn, PD 2007, Gender, sex steroids, and cerebral ischemic pathobiology. in Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, pp. 185-207. https://doi.org/10.1007/978-0-387-30383-3_11
Koerner I, Murphy SJ, Hurn PD. Gender, sex steroids, and cerebral ischemic pathobiology. In Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US. 2007. p. 185-207 https://doi.org/10.1007/978-0-387-30383-3_11
Koerner, Ines ; Murphy, S. J. ; Hurn, P. D. / Gender, sex steroids, and cerebral ischemic pathobiology. Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, 2007. pp. 185-207
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