Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides

Bruce F. Bebo, Jeanette C. Schuster, Arthur Vandenbark, Halina Offner

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Multiple sclerosis (MS) strikes women more often than men. Gender differences in experimental autoimmune encephalomyelitis (EAE) parallel those seen in MS. We utilized the adoptive transfer model of EAE to determine the role of gender on the induction and effector phases of disease. PLP 139-151- sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However, there were no gender differences in the frequency of PLP 139-151-specific T cells. PLP 139-151- specific female T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase.

Original languageEnglish (US)
Pages (from-to)420-426
Number of pages7
JournalJournal of Neuroscience Research
Volume52
Issue number4
DOIs
StatePublished - May 15 1998

Fingerprint

Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Peptides
Multiple Sclerosis
Cell Line
Adoptive Transfer
Spleen
Tissue Donors
myelin proteolipid protein (139-151)

Keywords

  • Multiple sclerosis
  • Proteolipid protein
  • Sex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{23e415152d2d48c88f9e7983d1bcf505,
title = "Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides",
abstract = "Multiple sclerosis (MS) strikes women more often than men. Gender differences in experimental autoimmune encephalomyelitis (EAE) parallel those seen in MS. We utilized the adoptive transfer model of EAE to determine the role of gender on the induction and effector phases of disease. PLP 139-151- sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However, there were no gender differences in the frequency of PLP 139-151-specific T cells. PLP 139-151- specific female T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase.",
keywords = "Multiple sclerosis, Proteolipid protein, Sex",
author = "Bebo, {Bruce F.} and Schuster, {Jeanette C.} and Arthur Vandenbark and Halina Offner",
year = "1998",
month = "5",
day = "15",
doi = "10.1002/(SICI)1097-4547(19980515)52:4<420::AID-JNR5>3.0.CO;2-B",
language = "English (US)",
volume = "52",
pages = "420--426",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides

AU - Bebo, Bruce F.

AU - Schuster, Jeanette C.

AU - Vandenbark, Arthur

AU - Offner, Halina

PY - 1998/5/15

Y1 - 1998/5/15

N2 - Multiple sclerosis (MS) strikes women more often than men. Gender differences in experimental autoimmune encephalomyelitis (EAE) parallel those seen in MS. We utilized the adoptive transfer model of EAE to determine the role of gender on the induction and effector phases of disease. PLP 139-151- sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However, there were no gender differences in the frequency of PLP 139-151-specific T cells. PLP 139-151- specific female T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase.

AB - Multiple sclerosis (MS) strikes women more often than men. Gender differences in experimental autoimmune encephalomyelitis (EAE) parallel those seen in MS. We utilized the adoptive transfer model of EAE to determine the role of gender on the induction and effector phases of disease. PLP 139-151- sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However, there were no gender differences in the frequency of PLP 139-151-specific T cells. PLP 139-151- specific female T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase.

KW - Multiple sclerosis

KW - Proteolipid protein

KW - Sex

UR - http://www.scopus.com/inward/record.url?scp=2642648645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2642648645&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-4547(19980515)52:4<420::AID-JNR5>3.0.CO;2-B

DO - 10.1002/(SICI)1097-4547(19980515)52:4<420::AID-JNR5>3.0.CO;2-B

M3 - Article

C2 - 9589386

AN - SCOPUS:2642648645

VL - 52

SP - 420

EP - 426

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 4

ER -