Gastrointestinal multicentric infantile myofibromatosis: Characteristic histology on rectal biopsy

P. Stenzel, S. Fitterer

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

A 10-wk-old girl with growth failure and increasingly severe watery diarrhea underwent rectal biopsy which revealed diffuse mucosal fibrosis. Subsequent histologic study of mediastinal and subcutaneous masses established the diagnosis of multicentric infantile myofibromatosis. The patient died at 16 wk of age with tumor nodules in several visceral and parietal structures. The small and large intestines contained continuous, diffuse and nodular, mucosal and submucosal fibrosis. Twelve previously reported cases of multicentric infantile myofibromatosis involved the gastrointestinal tract; four had prominent gastrointestinal clinical manifestations. In two, diarrhea was prominent. The present case demonstrates the potential value of rectal biopsy in the diagnosis of infantile myofibromatosis with gastrointestinal manifestations.

Original languageEnglish (US)
Pages (from-to)1115-1119
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume84
Issue number9
StatePublished - Jan 1 1989

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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