Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons

Hidehiko Shogomori, Michelle A. Burack, Gary Banker, Anthony H. Futerman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalFEBS Letters
Volume458
Issue number2
DOIs
StatePublished - Sep 17 1999

Fingerprint

G(M1) Ganglioside
Neurons
Cholera Toxin
Cell membranes
Cell Membrane
Membranes
Proteins

Keywords

  • Axon
  • Cholera toxin
  • Dendrite
  • Ganglioside
  • Neuron
  • Polarity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Shogomori, H., Burack, M. A., Banker, G., & Futerman, A. H. (1999). Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. FEBS Letters, 458(2), 107-111. https://doi.org/10.1016/S0014-5793(99)01146-1

Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. / Shogomori, Hidehiko; Burack, Michelle A.; Banker, Gary; Futerman, Anthony H.

In: FEBS Letters, Vol. 458, No. 2, 17.09.1999, p. 107-111.

Research output: Contribution to journalArticle

Shogomori, H, Burack, MA, Banker, G & Futerman, AH 1999, 'Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons', FEBS Letters, vol. 458, no. 2, pp. 107-111. https://doi.org/10.1016/S0014-5793(99)01146-1
Shogomori, Hidehiko ; Burack, Michelle A. ; Banker, Gary ; Futerman, Anthony H. / Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. In: FEBS Letters. 1999 ; Vol. 458, No. 2. pp. 107-111.
@article{f6b798bdc3a3422bafed6811db4a00b9,
title = "Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons",
abstract = "Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. Copyright (C) 1999 Federation of European Biochemical Societies.",
keywords = "Axon, Cholera toxin, Dendrite, Ganglioside, Neuron, Polarity",
author = "Hidehiko Shogomori and Burack, {Michelle A.} and Gary Banker and Futerman, {Anthony H.}",
year = "1999",
month = "9",
day = "17",
doi = "10.1016/S0014-5793(99)01146-1",
language = "English (US)",
volume = "458",
pages = "107--111",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons

AU - Shogomori, Hidehiko

AU - Burack, Michelle A.

AU - Banker, Gary

AU - Futerman, Anthony H.

PY - 1999/9/17

Y1 - 1999/9/17

N2 - Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - Axon

KW - Cholera toxin

KW - Dendrite

KW - Ganglioside

KW - Neuron

KW - Polarity

UR - http://www.scopus.com/inward/record.url?scp=0032867874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032867874&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(99)01146-1

DO - 10.1016/S0014-5793(99)01146-1

M3 - Article

C2 - 10481046

AN - SCOPUS:0032867874

VL - 458

SP - 107

EP - 111

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 2

ER -