Ganglionic tyrosine hydroxylase and norepinephrine transporter are decreased by increased sodium chloride in vivo and in vitro

Beth Habecker, Eugene T. Grygielko, Timothy A. Huhtala, Billy Foote, Virginia Brooks

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The present study tested the hypothesis that, in normal male rats, chronic changes in salt intake alter the levels of tyrosine hydroxylase and the norepinephrine transporter in sympathetic ganglia. Increasing dietary salt (from 0.02% to 1%, 4% or 8% NaCl in rat chow) decreased (p-1 (p-1. These data suggest that increased dietary salt can influence the activity of the sympathetic nervous system by suppressing the levels of tyrosine hydroxylase and the norepinephrine transporter. While increased NaCl levels can act directly on neurons to suppress these proteins, this action may occur in vivo only in severe pathophysiological states, but not during increases in dietary salt without the synergistic effect of other factors.

Original languageEnglish (US)
Pages (from-to)85-98
Number of pages14
JournalAutonomic Neuroscience: Basic and Clinical
Volume107
Issue number2
DOIs
StatePublished - Sep 30 2003

Fingerprint

Norepinephrine Plasma Membrane Transport Proteins
Tyrosine 3-Monooxygenase
Sodium Chloride
Salts
Sympathetic Ganglia
Sympathetic Nervous System
Neurons
In Vitro Techniques
Proteins

Keywords

  • Adrenal
  • Celiac ganglia
  • NE uptake
  • Plasma sodium concentration
  • Rat
  • Salt intake
  • Superior cervical ganglia
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Ganglionic tyrosine hydroxylase and norepinephrine transporter are decreased by increased sodium chloride in vivo and in vitro. / Habecker, Beth; Grygielko, Eugene T.; Huhtala, Timothy A.; Foote, Billy; Brooks, Virginia.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 107, No. 2, 30.09.2003, p. 85-98.

Research output: Contribution to journalArticle

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