Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency

S. S. Johansen, X. Wang, D. Sejer Pedersen, P. L. Pearl, Jean-Baptiste Roullet, G. R. Ainslie, K. R. Vogel, K. M. Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Gamma-hydroxybutyrate (GHB) is a drug of abuse, an approved therapeutic for narcolepsy, an agent employed for facilitation of sexual assault, as well as a biomarker of succinic semialdehyde dehydrogenase deficiency (SSADHD). Our laboratory seeks to identify surrogate biomarkers in SSADHD that can shed light on the developmental course of this neurometabolic disease. Since GHB may be quantified in hair as a potential surrogate to identify victims of drug-related assault, we have opted to examine its level in SSADHD. We quantified GHB in hair derived from ten patients with SSADHD, and documented a significant negative age correlation. These findings are consistent with recent results in patient biological fluids, including plasma and red blood cells. These findings may provide additional insight into the developmental course of SSADHD (Jansen et al., J Inherit Metab Dis 39:795–800, 2016).

Original languageEnglish (US)
Title of host publicationJIMD Reports
PublisherSpringer
Pages93-98
Number of pages6
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Publication series

NameJIMD Reports
Volume36
ISSN (Print)2192-8304
ISSN (Electronic)2192-8312

Fingerprint

Succinate-Semialdehyde Dehydrogenase
Sodium Oxybate
Hair
Biomarkers
Narcolepsy
Street Drugs
Blood
Erythrocytes
Cells
succinic semialdehyde dehydrogenase deficiency
Plasmas
Fluids
Pharmaceutical Preparations

Keywords

  • GABA metabolism
  • Gamma-hydroxybutyrate (GHB)
  • Hair analysis
  • Succinic semialdehyde dehydrogenase (SSADH)
  • Succinic semialdehyde dehydrogenase deficiency (SSADHD)
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Johansen, S. S., Wang, X., Sejer Pedersen, D., Pearl, P. L., Roullet, J-B., Ainslie, G. R., ... Gibson, K. M. (2017). Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency. In JIMD Reports (pp. 93-98). (JIMD Reports; Vol. 36). Springer. https://doi.org/10.1007/8904_2017_3

Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency. / Johansen, S. S.; Wang, X.; Sejer Pedersen, D.; Pearl, P. L.; Roullet, Jean-Baptiste; Ainslie, G. R.; Vogel, K. R.; Gibson, K. M.

JIMD Reports. Springer, 2017. p. 93-98 (JIMD Reports; Vol. 36).

Research output: Chapter in Book/Report/Conference proceedingChapter

Johansen, SS, Wang, X, Sejer Pedersen, D, Pearl, PL, Roullet, J-B, Ainslie, GR, Vogel, KR & Gibson, KM 2017, Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency. in JIMD Reports. JIMD Reports, vol. 36, Springer, pp. 93-98. https://doi.org/10.1007/8904_2017_3
Johansen SS, Wang X, Sejer Pedersen D, Pearl PL, Roullet J-B, Ainslie GR et al. Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency. In JIMD Reports. Springer. 2017. p. 93-98. (JIMD Reports). https://doi.org/10.1007/8904_2017_3
Johansen, S. S. ; Wang, X. ; Sejer Pedersen, D. ; Pearl, P. L. ; Roullet, Jean-Baptiste ; Ainslie, G. R. ; Vogel, K. R. ; Gibson, K. M. / Gamma-hydroxybutyrate (GHB) content in hair samples correlates negatively with age in succinic semialdehyde dehydrogenase deficiency. JIMD Reports. Springer, 2017. pp. 93-98 (JIMD Reports).
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