Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement

Bartley G. Hoebel, Gregory Mark, Pedro V. Rada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).

Original languageEnglish (US)
Pages (from-to)83
Number of pages1
JournalAppetite
Volume24
Issue number1
StatePublished - 1995
Externally publishedYes

Fingerprint

Galanin
Paraventricular Hypothalamic Nucleus
Nucleus Accumbens
Acetylcholine
Dopamine
Injections
Food
United States Public Health Service
Organized Financing
Neuropeptide Y
Eating
Reinforcement (Psychology)

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement. / Hoebel, Bartley G.; Mark, Gregory; Rada, Pedro V.

In: Appetite, Vol. 24, No. 1, 1995, p. 83.

Research output: Contribution to journalArticle

@article{c17077b842ba4053889408c6cdcc503c,
title = "Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement",
abstract = "Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152{\%} of baseline, n = 8) and a concomitant decrease in ACh (75{\%} of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).",
author = "Hoebel, {Bartley G.} and Gregory Mark and Rada, {Pedro V.}",
year = "1995",
language = "English (US)",
volume = "24",
pages = "83",
journal = "Appetite",
issn = "0195-6663",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement

AU - Hoebel, Bartley G.

AU - Mark, Gregory

AU - Rada, Pedro V.

PY - 1995

Y1 - 1995

N2 - Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).

AB - Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).

UR - http://www.scopus.com/inward/record.url?scp=0010523610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0010523610&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 83

JO - Appetite

JF - Appetite

SN - 0195-6663

IS - 1

ER -