Abstract
Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83 |
| Number of pages | 1 |
| Journal | Appetite |
| Volume | 24 |
| Issue number | 1 |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement. / Hoebel, Bartley G.; Mark, Gregory; Rada, Pedro V.
In: Appetite, Vol. 24, No. 1, 1995, p. 83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Galanin injected into the hypothalamic PVN increases dopamine release and decreases acetylcholine in the nucleus accumbens system for behavior reinforcement
AU - Hoebel, Bartley G.
AU - Mark, Gregory
AU - Rada, Pedro V.
PY - 1995
Y1 - 1995
N2 - Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).
AB - Galanin (GAL, 300 pmol), neuropeptide Y (NPY, 78 pmol) and saline were each injected ipsilaterally into the paraventricular nucleus (PVN) while extracellular dopamine (DA) and acetylcholine (ACh) were monitored in the nucleus accumbens (NAc). On a later day, injections were repeated in the same rats with food pellets available and intake measured. The result with GAL was a significant increase in DA (152% of baseline, n = 8) and a concomitant decrease in ACh (75% of baseline, n = 7). This was observed only in the animals that later proved to eat in response to GAL. Injections of NPY were without effect on DA and ACh whether they induced feeding or not. Saline injections had no effects. We conclude that when GAL in the PVN activates a circuit for eating food, it also activates circuitry that releases DA and inhibits ACh release in the NAc. This may be the link from a hypothalamic feeding mechanism to a NAc system for initiation and reinforcement of behavior. (Supported by USPHS grant NS 30697.).
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UR - http://www.scopus.com/inward/citedby.url?scp=0010523610&partnerID=8YFLogxK
M3 - Article
VL - 24
SP - 83
JO - Appetite
JF - Appetite
SN - 0195-6663
IS - 1
ER -