Abstract
Gadolinium diethylenetriamine pentaacetic acid (DTPA) enhanced magnetic resonance imaging was performed in eight patients with Cushing disease and surgically proven pituitary microadenomas. A 1.5 T scanner was used with 3 mm contiguous slices. Short repetition times (TR), short echo times (TE), and long TR, long TE sequences were obtained before and serially after intravenous administration of Gd-DTPA. Three of eight (38%) microadenomas were undetectable both without and with Gd-DTPA: one post-Gd-DTPA scan was false positive on the side opposite the adenoma. Hemihy-pophysectomy based on a petrosal sinus adrenocorticotropic hormone (ACTH) gradient cured all three patients. Two microadenomas (25%) were visible as hypointense foci following Gd-DTPA but not on unenhanced scans. The remaining three microadenomas (38%) were seen before and after Gd-DTPA on Tl-weighted images. In this small series of ACTH-producing microadenomas, one-third were seen on unenhanced 1.5 T scans, one-third were seen only after Gd-DTPA, and one-third were not imaged even with Gd-DTPA enhancement.
Original language | English (US) |
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Pages (from-to) | 728-735 |
Number of pages | 8 |
Journal | Journal of Computer Assisted Tomography |
Volume | 12 |
Issue number | 5 |
DOIs | |
State | Published - Sep 1988 |
Externally published | Yes |
Keywords
- ACTH
- Contrast medium
- Magnetic resonance imaging
- Neoplasms
- Pituitary gland
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging