GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Alcohol (ethanol) is a widely used and abused drug with approximately 90% of adults over the age of 18 consuming alcohol at some point in their lifetime. Alcohol exerts its actions through multiple neurotransmitter systems within the brain, most notably the GABAergic and glutamatergic systems. Alcohol’s actions on GABAergic and glutamatergic neurotransmission have been suggested to underlie the acute behavioral effects of ethanol. The striatum is the primary input nucleus of the basal ganglia that plays a role in motor and reward systems. The effect of ethanol on GABAergic and glutamatergic neurotransmission within striatal circuitry has been thought to underlie ethanol taking, seeking, withdrawal and relapse. This chapter reviews the effects of ethanol on GABAergic and glutamatergic transmission, highlighting the dynamic changes in striatal circuitry from acute to chronic exposure and withdrawal.

    Original languageEnglish (US)
    Title of host publicationHandbook of Experimental Pharmacology
    PublisherSpringer New York LLC
    Pages79-112
    Number of pages34
    DOIs
    StatePublished - Jan 1 2018

    Publication series

    NameHandbook of Experimental Pharmacology
    Volume248
    ISSN (Print)0171-2004
    ISSN (Electronic)1865-0325

    Fingerprint

    gamma-Aminobutyric Acid
    Glutamic Acid
    Ethanol
    Alcohols
    Corpus Striatum
    Synaptic Transmission
    Basal Ganglia
    Reward
    Neurotransmitter Agents
    Brain
    Recurrence
    Pharmaceutical Preparations

    Keywords

    • Action control
    • Addiction
    • Alcohol
    • Cortico-striatal loop
    • Neurotransmitter
    • Synaptic transmission

    ASJC Scopus subject areas

    • Biochemistry
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Cuzon Carlson, V. (2018). GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. In Handbook of Experimental Pharmacology (pp. 79-112). (Handbook of Experimental Pharmacology; Vol. 248). Springer New York LLC. https://doi.org/10.1007/164_2018_98

    GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. / Cuzon Carlson, Verginia.

    Handbook of Experimental Pharmacology. Springer New York LLC, 2018. p. 79-112 (Handbook of Experimental Pharmacology; Vol. 248).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cuzon Carlson, V 2018, GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. in Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology, vol. 248, Springer New York LLC, pp. 79-112. https://doi.org/10.1007/164_2018_98
    Cuzon Carlson V. GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. In Handbook of Experimental Pharmacology. Springer New York LLC. 2018. p. 79-112. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/164_2018_98
    Cuzon Carlson, Verginia. / GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum. Handbook of Experimental Pharmacology. Springer New York LLC, 2018. pp. 79-112 (Handbook of Experimental Pharmacology).
    @inbook{793ab5c798cd48ab9f43f340e2ae06e6,
    title = "GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum",
    abstract = "Alcohol (ethanol) is a widely used and abused drug with approximately 90{\%} of adults over the age of 18 consuming alcohol at some point in their lifetime. Alcohol exerts its actions through multiple neurotransmitter systems within the brain, most notably the GABAergic and glutamatergic systems. Alcohol’s actions on GABAergic and glutamatergic neurotransmission have been suggested to underlie the acute behavioral effects of ethanol. The striatum is the primary input nucleus of the basal ganglia that plays a role in motor and reward systems. The effect of ethanol on GABAergic and glutamatergic neurotransmission within striatal circuitry has been thought to underlie ethanol taking, seeking, withdrawal and relapse. This chapter reviews the effects of ethanol on GABAergic and glutamatergic transmission, highlighting the dynamic changes in striatal circuitry from acute to chronic exposure and withdrawal.",
    keywords = "Action control, Addiction, Alcohol, Cortico-striatal loop, Neurotransmitter, Synaptic transmission",
    author = "{Cuzon Carlson}, Verginia",
    year = "2018",
    month = "1",
    day = "1",
    doi = "10.1007/164_2018_98",
    language = "English (US)",
    series = "Handbook of Experimental Pharmacology",
    publisher = "Springer New York LLC",
    pages = "79--112",
    booktitle = "Handbook of Experimental Pharmacology",

    }

    TY - CHAP

    T1 - GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum

    AU - Cuzon Carlson, Verginia

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Alcohol (ethanol) is a widely used and abused drug with approximately 90% of adults over the age of 18 consuming alcohol at some point in their lifetime. Alcohol exerts its actions through multiple neurotransmitter systems within the brain, most notably the GABAergic and glutamatergic systems. Alcohol’s actions on GABAergic and glutamatergic neurotransmission have been suggested to underlie the acute behavioral effects of ethanol. The striatum is the primary input nucleus of the basal ganglia that plays a role in motor and reward systems. The effect of ethanol on GABAergic and glutamatergic neurotransmission within striatal circuitry has been thought to underlie ethanol taking, seeking, withdrawal and relapse. This chapter reviews the effects of ethanol on GABAergic and glutamatergic transmission, highlighting the dynamic changes in striatal circuitry from acute to chronic exposure and withdrawal.

    AB - Alcohol (ethanol) is a widely used and abused drug with approximately 90% of adults over the age of 18 consuming alcohol at some point in their lifetime. Alcohol exerts its actions through multiple neurotransmitter systems within the brain, most notably the GABAergic and glutamatergic systems. Alcohol’s actions on GABAergic and glutamatergic neurotransmission have been suggested to underlie the acute behavioral effects of ethanol. The striatum is the primary input nucleus of the basal ganglia that plays a role in motor and reward systems. The effect of ethanol on GABAergic and glutamatergic neurotransmission within striatal circuitry has been thought to underlie ethanol taking, seeking, withdrawal and relapse. This chapter reviews the effects of ethanol on GABAergic and glutamatergic transmission, highlighting the dynamic changes in striatal circuitry from acute to chronic exposure and withdrawal.

    KW - Action control

    KW - Addiction

    KW - Alcohol

    KW - Cortico-striatal loop

    KW - Neurotransmitter

    KW - Synaptic transmission

    UR - http://www.scopus.com/inward/record.url?scp=85063950824&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85063950824&partnerID=8YFLogxK

    U2 - 10.1007/164_2018_98

    DO - 10.1007/164_2018_98

    M3 - Chapter

    C2 - 29460153

    AN - SCOPUS:85063950824

    T3 - Handbook of Experimental Pharmacology

    SP - 79

    EP - 112

    BT - Handbook of Experimental Pharmacology

    PB - Springer New York LLC

    ER -