G Protein-Coupled Receptors in Myelinating Glia

Amit Mogha, Mitchell D'Rozario, Kelly R. Monk

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The G protein-coupled receptor (GPCR) superfamily represents the largest class of functionally selective drug targets for disease modulation and therapy. GPCRs have been studied in great detail in central nervous system (CNS) neurons, but these important molecules have been relatively understudied in glia. In recent years, however, exciting new roles for GPCRs in glial cell biology have emerged. We focus here on the key roles of GPCRs in a specialized subset of glia, myelinating glia. We highlight recent work firmly establishing GPCRs as regulators of myelinating glial cell development and myelin repair. These advances expand our understanding of myelinating glial cell biology and underscore the utility of targeting GPCRs to promote myelin repair in human disease.

Original languageEnglish (US)
Pages (from-to)977-987
Number of pages11
JournalTrends in pharmacological sciences
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • G protein-coupled receptor (GPCR)
  • Schwann cell
  • myelination
  • oligodendrocyte
  • remyelination

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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