G-Protein-Coupled Receptor SRBC-48 Protects against Dendrite Degeneration and Reduced Longevity Due to Infection

Supender Kaur, Alejandro Aballay

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Increasing evidence suggests that deficient immune modulation and microbial infections underline neurodegeneration, but the mechanisms remain obscure. Here, we show that the G-protein-coupled receptor (GPCR) SRBC-48, which belongs to the class BC serpentine receptors, has a protective role in Caenorhabditis elegans dendrite degeneration caused by Pseudomonas aeruginosa infection. Our results indicate that SRBC-48 functions in a cell-autonomous manner in AWC neurons to protect against infection-associated dendrite degeneration. The absence of SRBC-48 results in a reduced lifespan caused by a pathogen infection early in life that induces dendrite degeneration. The decreased longevity in animals deficient in SRBC-48 is due to uncontrolled activation of immune genes, particularly those regulated by the FOXO family transcription factor DAF-16 that is part of the insulin/insulin-like growth factor (IGF)-1 receptor homolog DAF-2. These results reveal how an infection early in life can not only induce dendrite degeneration but also reduce lifespan.

Original languageEnglish (US)
Article number107662
JournalCell Reports
Volume31
Issue number7
DOIs
StatePublished - May 19 2020

Keywords

  • Caenorhabditis elegans
  • DAF-16
  • G-protein-coupled receptor
  • Pseudomonas aeruginosa
  • SRBC-48
  • infection
  • inflammation
  • longevity
  • neurodegeneration
  • pathogens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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