Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level–dependent contrast

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Abstract

Purpose: To characterize spatial patterns of T* 2 in the placenta of the rhesus macaque (Macaca mulatta), to correlate these patterns with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and to evaluate the potential for using the blood oxygen level–dependent effect to quantify placental perfusion without the use of exogenous contrast reagent. Methods: MRI was performed on three pregnant rhesus macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used to compute maps of T* 2. Spatial maxima in these maps were compared with foci of early enhancement determined by DCE-MRI. Results: Local maxima in T* 2 maps were strongly correlated with spiral arteries identified by DCE-MRI, with mean spatial separations ranging from 2.34 to 6.11 mm in the three animals studied. Spatial patterns of T* 2 (= 1/ T* 2) within individual placental lobules can be quantitatively analyzed using a simple model to estimate fetal arterial oxyhemoglobin concentration [Hbo, f] and a parameter viPS/ɸ, reflecting oxygen transport to the fetus. Estimated mean values of [Hbo, f] ranged from 4.25 mM to 4.46 mM, whereas viPS/ɸ ranged from 2.80 × 105 cm−3 to 1.61 × 106 cm−3. Conclusions: Maternal spiral arteries show strong spatial correlation with foci of extended T* 2 observed in the primate placenta. A simple model of oxygen transport accurately describes the spatial dependence of R* 2 within placental lobules and enables assessment of placental function and oxygenation without requiring administration of an exogenous contrast reagent. Magn Reson Med 76:1551–1562, 2016.

Original languageEnglish (US)
Pages (from-to)1551-1562
Number of pages12
JournalMagnetic Resonance in Medicine
Volume76
Issue number5
DOIs
StatePublished - Nov 1 2016

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Macaca mulatta
Placenta
Primates
Oxygen
Arteries
Perfusion
Oxyhemoglobins
Fetus
Mothers

Keywords

  • BOLD MRI
  • DCE-MRI
  • Placenta
  • Pregnancy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{3ddb0429dcb14ccdbff2c58e9628552e,
title = "Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level–dependent contrast",
abstract = "Purpose: To characterize spatial patterns of T* 2 in the placenta of the rhesus macaque (Macaca mulatta), to correlate these patterns with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and to evaluate the potential for using the blood oxygen level–dependent effect to quantify placental perfusion without the use of exogenous contrast reagent. Methods: MRI was performed on three pregnant rhesus macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used to compute maps of T* 2. Spatial maxima in these maps were compared with foci of early enhancement determined by DCE-MRI. Results: Local maxima in T* 2 maps were strongly correlated with spiral arteries identified by DCE-MRI, with mean spatial separations ranging from 2.34 to 6.11 mm in the three animals studied. Spatial patterns of T* 2 (= 1/ T* 2) within individual placental lobules can be quantitatively analyzed using a simple model to estimate fetal arterial oxyhemoglobin concentration [Hbo, f] and a parameter viPS/ɸ, reflecting oxygen transport to the fetus. Estimated mean values of [Hbo, f] ranged from 4.25 mM to 4.46 mM, whereas viPS/ɸ ranged from 2.80 × 105 cm−3 to 1.61 × 106 cm−3. Conclusions: Maternal spiral arteries show strong spatial correlation with foci of extended T* 2 observed in the primate placenta. A simple model of oxygen transport accurately describes the spatial dependence of R* 2 within placental lobules and enables assessment of placental function and oxygenation without requiring administration of an exogenous contrast reagent. Magn Reson Med 76:1551–1562, 2016.",
keywords = "BOLD MRI, DCE-MRI, Placenta, Pregnancy",
author = "Matthias Schabel and Victoria Roberts and Jamie Lo and Sarah Platt and Grant, {Kathleen (Kathy)} and Antonio Frias and Kroenke, {Christopher (Chris)}",
year = "2016",
month = "11",
day = "1",
doi = "10.1002/mrm.26052",
language = "English (US)",
volume = "76",
pages = "1551--1562",
journal = "Magnetic Resonance in Medicine",
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TY - JOUR

T1 - Functional imaging of the nonhuman primate Placenta with endogenous blood oxygen level–dependent contrast

AU - Schabel, Matthias

AU - Roberts, Victoria

AU - Lo, Jamie

AU - Platt, Sarah

AU - Grant, Kathleen (Kathy)

AU - Frias, Antonio

AU - Kroenke, Christopher (Chris)

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Purpose: To characterize spatial patterns of T* 2 in the placenta of the rhesus macaque (Macaca mulatta), to correlate these patterns with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and to evaluate the potential for using the blood oxygen level–dependent effect to quantify placental perfusion without the use of exogenous contrast reagent. Methods: MRI was performed on three pregnant rhesus macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used to compute maps of T* 2. Spatial maxima in these maps were compared with foci of early enhancement determined by DCE-MRI. Results: Local maxima in T* 2 maps were strongly correlated with spiral arteries identified by DCE-MRI, with mean spatial separations ranging from 2.34 to 6.11 mm in the three animals studied. Spatial patterns of T* 2 (= 1/ T* 2) within individual placental lobules can be quantitatively analyzed using a simple model to estimate fetal arterial oxyhemoglobin concentration [Hbo, f] and a parameter viPS/ɸ, reflecting oxygen transport to the fetus. Estimated mean values of [Hbo, f] ranged from 4.25 mM to 4.46 mM, whereas viPS/ɸ ranged from 2.80 × 105 cm−3 to 1.61 × 106 cm−3. Conclusions: Maternal spiral arteries show strong spatial correlation with foci of extended T* 2 observed in the primate placenta. A simple model of oxygen transport accurately describes the spatial dependence of R* 2 within placental lobules and enables assessment of placental function and oxygenation without requiring administration of an exogenous contrast reagent. Magn Reson Med 76:1551–1562, 2016.

AB - Purpose: To characterize spatial patterns of T* 2 in the placenta of the rhesus macaque (Macaca mulatta), to correlate these patterns with placental perfusion determined using dynamic contrast-enhanced MRI (DCE-MRI), and to evaluate the potential for using the blood oxygen level–dependent effect to quantify placental perfusion without the use of exogenous contrast reagent. Methods: MRI was performed on three pregnant rhesus macaques at gestational day 110. Multiecho spoiled gradient echo measurements were used to compute maps of T* 2. Spatial maxima in these maps were compared with foci of early enhancement determined by DCE-MRI. Results: Local maxima in T* 2 maps were strongly correlated with spiral arteries identified by DCE-MRI, with mean spatial separations ranging from 2.34 to 6.11 mm in the three animals studied. Spatial patterns of T* 2 (= 1/ T* 2) within individual placental lobules can be quantitatively analyzed using a simple model to estimate fetal arterial oxyhemoglobin concentration [Hbo, f] and a parameter viPS/ɸ, reflecting oxygen transport to the fetus. Estimated mean values of [Hbo, f] ranged from 4.25 mM to 4.46 mM, whereas viPS/ɸ ranged from 2.80 × 105 cm−3 to 1.61 × 106 cm−3. Conclusions: Maternal spiral arteries show strong spatial correlation with foci of extended T* 2 observed in the primate placenta. A simple model of oxygen transport accurately describes the spatial dependence of R* 2 within placental lobules and enables assessment of placental function and oxygenation without requiring administration of an exogenous contrast reagent. Magn Reson Med 76:1551–1562, 2016.

KW - BOLD MRI

KW - DCE-MRI

KW - Placenta

KW - Pregnancy

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