Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research

L. Marie Scearce; John E. Brestelli; Shannon K. McWeeney; Catherine S. Lee; Joan Mazzarelli; Deborah F. Pinney; Angel Pizarro; Christian J. Stoeckert; Sandra W. Clifton; M. Alan Permutt; Juliana Brown; Douglas A. Melton; Klaus H. Kaestner

doi:10.2337/diabetes.51.7.1997

Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research

L. Marie Scearce, John E. Brestelli, Shannon K. McWeeney, Catherine S. Lee, Joan Mazzarelli, Deborah F. Pinney, Angel Pizarro, Christian J. Stoeckert, Sandra W. Clifton, M. Alan Permutt, Juliana Brown, Douglas A. Melton, Klaus H. Kaestner

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Over the past 5 years, microarrays have greatly facilitated large-scale analysis of gene expression levels, Although these arrays were not specifically geared to represent tissues and pathways known to be affected by diabetes, they have been used in both type 1 and type 2 diabetes research. To prepare a tool that is particularly useful in the study of type 1 diabetes, we have assembled a nonredundant set of 3,400 clones representing genes expressed in the mouse pancreas or pathways known to be affected by diabetes. We have demonstrated the usefulness of this clone set by preparing a cDNA glass microarray, the PancChip, and using it to analyze pancreatic gene expression from embryonic day 14.5 through adulthood in mice. The clone set and corresponding array are useful resources for diabetes research.

Original language	English (US)
Pages (from-to)	1997-2004
Number of pages	8
Journal	Diabetes
Volume	51
Issue number	7
DOIs	https://doi.org/10.2337/diabetes.51.7.1997
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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Marie Scearce, L., Brestelli, J. E., McWeeney, S. K., Lee, C. S., Mazzarelli, J., Pinney, D. F., Pizarro, A., Stoeckert, C. J., Clifton, S. W., Alan Permutt, M., Brown, J., Melton, D. A., & Kaestner, K. H. (2002). Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research. Diabetes, 51(7), 1997-2004. https://doi.org/10.2337/diabetes.51.7.1997

Marie Scearce, L, Brestelli, JE, McWeeney, SK, Lee, CS, Mazzarelli, J, Pinney, DF, Pizarro, A, Stoeckert, CJ, Clifton, SW, Alan Permutt, M, Brown, J, Melton, DA & Kaestner, KH 2002, 'Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research', Diabetes, vol. 51, no. 7, pp. 1997-2004. https://doi.org/10.2337/diabetes.51.7.1997

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AU - Mazzarelli, Joan

AU - Pinney, Deborah F.

AU - Pizarro, Angel

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Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research

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ASJC Scopus subject areas

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