Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research

L. Marie Scearce, John E. Brestelli, Shannon K. McWeeney, Catherine S. Lee, Joan Mazzarelli, Deborah F. Pinney, Angel Pizarro, Christian J. Stoeckert, Sandra W. Clifton, M. Alan Permutt, Juliana Brown, Douglas A. Melton, Klaus H. Kaestner

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Over the past 5 years, microarrays have greatly facilitated large-scale analysis of gene expression levels, Although these arrays were not specifically geared to represent tissues and pathways known to be affected by diabetes, they have been used in both type 1 and type 2 diabetes research. To prepare a tool that is particularly useful in the study of type 1 diabetes, we have assembled a nonredundant set of 3,400 clones representing genes expressed in the mouse pancreas or pathways known to be affected by diabetes. We have demonstrated the usefulness of this clone set by preparing a cDNA glass microarray, the PancChip, and using it to analyze pancreatic gene expression from embryonic day 14.5 through adulthood in mice. The clone set and corresponding array are useful resources for diabetes research.

Original languageEnglish (US)
Pages (from-to)1997-2004
Number of pages8
JournalDiabetes
Volume51
Issue number7
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Marie Scearce, L., Brestelli, J. E., McWeeney, S. K., Lee, C. S., Mazzarelli, J., Pinney, D. F., Pizarro, A., Stoeckert, C. J., Clifton, S. W., Alan Permutt, M., Brown, J., Melton, D. A., & Kaestner, K. H. (2002). Functional genomics of the endocrine pancreas: The pancreas clone set and PancChip, new resources for diabetes research. Diabetes, 51(7), 1997-2004. https://doi.org/10.2337/diabetes.51.7.1997