Functional correlates of pallidal stimulation for Parkinson's disease

Masafumi Fukuda, Marc Mentis, Maria Felice Ghilardi, Vijay Dhawan, Angelo Antonini, John Hammerstad, Andres M. Lozano, Anthony Lang, Kelly Lyons, William Koller, Claude Ghez, David Eidelberg

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

We measured regional cerebral blood flow with H2 15O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right-handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication-free state. Internal globus pallidus deep brain stimulation improved off-state United Parkinson's Disease Rating Scale motor ratings (37%, p <0.002) and reduced timing errors (movement onset time, 55%, p <0.01) as well as spatial errors (10%, p <0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention.

Original languageEnglish (US)
Pages (from-to)155-164
Number of pages10
JournalAnnals of Neurology
Volume49
Issue number2
DOIs
StatePublished - 2001

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Cerebrovascular Circulation
Regional Blood Flow
Globus Pallidus
Deep Brain Stimulation
Parkinson Disease
Positron-Emission Tomography
Ventral Thalamic Nuclei
Neural Pathways
Gyrus Cinguli
Motor Cortex
Patient Rights
Cerebellum
Sensorimotor Cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Functional correlates of pallidal stimulation for Parkinson's disease. / Fukuda, Masafumi; Mentis, Marc; Ghilardi, Maria Felice; Dhawan, Vijay; Antonini, Angelo; Hammerstad, John; Lozano, Andres M.; Lang, Anthony; Lyons, Kelly; Koller, William; Ghez, Claude; Eidelberg, David.

In: Annals of Neurology, Vol. 49, No. 2, 2001, p. 155-164.

Research output: Contribution to journalArticle

Fukuda, M, Mentis, M, Ghilardi, MF, Dhawan, V, Antonini, A, Hammerstad, J, Lozano, AM, Lang, A, Lyons, K, Koller, W, Ghez, C & Eidelberg, D 2001, 'Functional correlates of pallidal stimulation for Parkinson's disease', Annals of Neurology, vol. 49, no. 2, pp. 155-164. https://doi.org/10.1002/1531-8249(20010201)49:2<155::AID-ANA35>3.0.CO;2-9
Fukuda, Masafumi ; Mentis, Marc ; Ghilardi, Maria Felice ; Dhawan, Vijay ; Antonini, Angelo ; Hammerstad, John ; Lozano, Andres M. ; Lang, Anthony ; Lyons, Kelly ; Koller, William ; Ghez, Claude ; Eidelberg, David. / Functional correlates of pallidal stimulation for Parkinson's disease. In: Annals of Neurology. 2001 ; Vol. 49, No. 2. pp. 155-164.
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