From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline

Ricardo E. Carrión, Deborah J. Walder, Andrea M. Auther, Danielle McLaughlin, Heather O. Zyla, Steven Adelsheim, Roderick Calkins, Cameron S. Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J. Daniel Ragland, Tamara G. Sale, Stephan F. Taylor, William R. McFarlane, Barbara A. Cornblatt

Research output: Research - peer-reviewArticle

Abstract

Cognitive deficits have an important role in the neurodevelopment of schizophrenia and other psychotic disorders. However, there is a continuing debate as to whether cognitive impairments in the psychosis prodrome are stable predictors of eventual psychosis or undergo a decline due to the onset of psychosis. In the present study, to determine how cognition changes as illness emerges, we examined baseline neurocognitive performance in a large sample of helping-seeking youth ranging in clinical state from low-risk for psychosis through individuals at clinical high-risk (CHR) for illness to early first-episode patients (EFEP). At baseline, the MATRICS Cognitive Consensus battery was administered to 322 individuals (205 CHRs, 28 EFEPs, and 89 help-seeking controls, HSC) that were part of the larger Early Detection, Intervention and Prevention of Psychosis Program study. CHR individuals were further divided into those who did (CHR-T; n = 12, 6.8%) and did not (CHR-NT, n = 163) convert to psychosis over follow-up (Mean = 99.20 weeks, SD = 21.54). ANCOVAs revealed that there were significant overall group differences (CHR, EFEP, HSC) in processing speed, verbal learning, and overall neurocognition, relative to healthy controls (CNTL). In addition, the CHR-NTs performed similarly to the HSC group, with mild to moderate cognitive deficits relative to the CTRL group. The CHR-Ts mirrored the EFEP group, with large deficits in processing speed, working memory, attention/vigilance, and verbal learning (>1 SD below CNTLs). Interestingly, only verbal learning impairments predicted transition to psychosis, when adjusting for age, education, symptoms, antipsychotic medication, and neurocognitive performance in the other domains. Our findings suggest that large neurocognitive deficits are present prior to illness onset and represent vulnerability markers for psychosis. The results of this study further reinforce that verbal learning should be specifically targeted for preventive intervention for psychosis.

LanguageEnglish (US)
Pages231-238
Number of pages8
JournalJournal of Psychiatric Research
Volume96
DOIs
StatePublished - Jan 1 2018

Fingerprint

Psychotic Disorders
Cognitive Dysfunction
Verbal Learning
Short-Term Memory
Cognition
Antipsychotic Agents
Schizophrenia
Consensus
Education

Keywords

  • Clinical high risk
  • Early Intervention
  • Early Psychosis
  • Neurocognition
  • Neuropsychology
  • Prodrome
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Carrión, R. E., Walder, D. J., Auther, A. M., McLaughlin, D., Zyla, H. O., Adelsheim, S., ... Cornblatt, B. A. (2018). From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline. Journal of Psychiatric Research, 96, 231-238. DOI: 10.1016/j.jpsychires.2017.10.014

From the psychosis prodrome to the first-episode of psychosis : No evidence of a cognitive decline. / Carrión, Ricardo E.; Walder, Deborah J.; Auther, Andrea M.; McLaughlin, Danielle; Zyla, Heather O.; Adelsheim, Steven; Calkins, Roderick; Carter, Cameron S.; McFarland, Bentson; Melton, Ryan; Niendam, Tara; Ragland, J. Daniel; Sale, Tamara G.; Taylor, Stephan F.; McFarlane, William R.; Cornblatt, Barbara A.

In: Journal of Psychiatric Research, Vol. 96, 01.01.2018, p. 231-238.

Research output: Research - peer-reviewArticle

Carrión, RE, Walder, DJ, Auther, AM, McLaughlin, D, Zyla, HO, Adelsheim, S, Calkins, R, Carter, CS, McFarland, B, Melton, R, Niendam, T, Ragland, JD, Sale, TG, Taylor, SF, McFarlane, WR & Cornblatt, BA 2018, 'From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline' Journal of Psychiatric Research, vol 96, pp. 231-238. DOI: 10.1016/j.jpsychires.2017.10.014
Carrión RE, Walder DJ, Auther AM, McLaughlin D, Zyla HO, Adelsheim S et al. From the psychosis prodrome to the first-episode of psychosis: No evidence of a cognitive decline. Journal of Psychiatric Research. 2018 Jan 1;96:231-238. Available from, DOI: 10.1016/j.jpsychires.2017.10.014
Carrión, Ricardo E. ; Walder, Deborah J. ; Auther, Andrea M. ; McLaughlin, Danielle ; Zyla, Heather O. ; Adelsheim, Steven ; Calkins, Roderick ; Carter, Cameron S. ; McFarland, Bentson ; Melton, Ryan ; Niendam, Tara ; Ragland, J. Daniel ; Sale, Tamara G. ; Taylor, Stephan F. ; McFarlane, William R. ; Cornblatt, Barbara A./ From the psychosis prodrome to the first-episode of psychosis : No evidence of a cognitive decline. In: Journal of Psychiatric Research. 2018 ; Vol. 96. pp. 231-238
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