Frequency of wetting is predictive of response to anticholinergic treatment in children with overactive bladder

Kyle J. Van Arendonk, James (Christopher) Austin, Margaret A. Boyt, Christopher S. Cooper

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives: To examine the variables relative to the response of oxybutynin treatment in children with daytime urinary incontinence. Methods: The records of patients seen for voiding problems between 1999 and 2003 were reviewed. Patients taking oxybutynin for 3 months or longer were included in the study. Patients with structural or neurologic bladder abnormalities and those taking oxybutynin at the initial visit were excluded. Age, sex, uroflowmetry findings, postvoid residual urine volume, duration and severity of symptoms before oxybutynin, urinary tract infection history, constipation, and the duration, dosage, and adverse effects of oxybutynin treatment were evaluated. Data were analyzed using Fisher's exact test for categorical variables, the two-sample t test or Wilcoxon rank-sum test for continuous and ordinal variables, and the linear mixed model analysis for uroflow data. Results: Eighty-one patients met the inclusion criteria. After an average follow-up of 1.2 years, 31 (38.3%) were dry, 25 (30.9%) had experienced significant improvement, 19 (23.5%) had experienced slight improvement, and 6 (7.4%) were unchanged. No significant differences were detected between those who became dry and those with little to no improvement with respect to age, sex, duration of symptoms, follow-up, uroflow pattern, postvoid residual urine volume, or bladder capacity. Those children presenting with decreased frequency of wetting episodes were significantly more likely to obtain daytime continence. The most common side effects were constipation (18.5%), dry mouth (17.3%), and flushing (13.6%). Conclusions: Children with daytime incontinence presenting with the lowest frequency of wetting were most likely to achieve continence. The frequency of wetting should be considered a significant prognostic variable when assessing the results of therapeutic intervention trials.

Original languageEnglish (US)
Pages (from-to)1049-1053
Number of pages5
JournalUrology
Volume67
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

Fingerprint

Overactive Urinary Bladder
Cholinergic Antagonists
Residual Volume
Constipation
Nonparametric Statistics
Diurnal Enuresis
Urinary Bladder
Urine
Nervous System Malformations
Therapeutics
Urinary Tract Infections
Mouth
Linear Models
oxybutynin

ASJC Scopus subject areas

  • Urology

Cite this

Frequency of wetting is predictive of response to anticholinergic treatment in children with overactive bladder. / Van Arendonk, Kyle J.; Austin, James (Christopher); Boyt, Margaret A.; Cooper, Christopher S.

In: Urology, Vol. 67, No. 5, 05.2006, p. 1049-1053.

Research output: Contribution to journalArticle

Van Arendonk, Kyle J. ; Austin, James (Christopher) ; Boyt, Margaret A. ; Cooper, Christopher S. / Frequency of wetting is predictive of response to anticholinergic treatment in children with overactive bladder. In: Urology. 2006 ; Vol. 67, No. 5. pp. 1049-1053.
@article{af410b4f7fa84da8bbb331b4e447b6e8,
title = "Frequency of wetting is predictive of response to anticholinergic treatment in children with overactive bladder",
abstract = "Objectives: To examine the variables relative to the response of oxybutynin treatment in children with daytime urinary incontinence. Methods: The records of patients seen for voiding problems between 1999 and 2003 were reviewed. Patients taking oxybutynin for 3 months or longer were included in the study. Patients with structural or neurologic bladder abnormalities and those taking oxybutynin at the initial visit were excluded. Age, sex, uroflowmetry findings, postvoid residual urine volume, duration and severity of symptoms before oxybutynin, urinary tract infection history, constipation, and the duration, dosage, and adverse effects of oxybutynin treatment were evaluated. Data were analyzed using Fisher's exact test for categorical variables, the two-sample t test or Wilcoxon rank-sum test for continuous and ordinal variables, and the linear mixed model analysis for uroflow data. Results: Eighty-one patients met the inclusion criteria. After an average follow-up of 1.2 years, 31 (38.3{\%}) were dry, 25 (30.9{\%}) had experienced significant improvement, 19 (23.5{\%}) had experienced slight improvement, and 6 (7.4{\%}) were unchanged. No significant differences were detected between those who became dry and those with little to no improvement with respect to age, sex, duration of symptoms, follow-up, uroflow pattern, postvoid residual urine volume, or bladder capacity. Those children presenting with decreased frequency of wetting episodes were significantly more likely to obtain daytime continence. The most common side effects were constipation (18.5{\%}), dry mouth (17.3{\%}), and flushing (13.6{\%}). Conclusions: Children with daytime incontinence presenting with the lowest frequency of wetting were most likely to achieve continence. The frequency of wetting should be considered a significant prognostic variable when assessing the results of therapeutic intervention trials.",
author = "{Van Arendonk}, {Kyle J.} and Austin, {James (Christopher)} and Boyt, {Margaret A.} and Cooper, {Christopher S.}",
year = "2006",
month = "5",
doi = "10.1016/j.urology.2005.11.060",
language = "English (US)",
volume = "67",
pages = "1049--1053",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Frequency of wetting is predictive of response to anticholinergic treatment in children with overactive bladder

AU - Van Arendonk, Kyle J.

AU - Austin, James (Christopher)

AU - Boyt, Margaret A.

AU - Cooper, Christopher S.

PY - 2006/5

Y1 - 2006/5

N2 - Objectives: To examine the variables relative to the response of oxybutynin treatment in children with daytime urinary incontinence. Methods: The records of patients seen for voiding problems between 1999 and 2003 were reviewed. Patients taking oxybutynin for 3 months or longer were included in the study. Patients with structural or neurologic bladder abnormalities and those taking oxybutynin at the initial visit were excluded. Age, sex, uroflowmetry findings, postvoid residual urine volume, duration and severity of symptoms before oxybutynin, urinary tract infection history, constipation, and the duration, dosage, and adverse effects of oxybutynin treatment were evaluated. Data were analyzed using Fisher's exact test for categorical variables, the two-sample t test or Wilcoxon rank-sum test for continuous and ordinal variables, and the linear mixed model analysis for uroflow data. Results: Eighty-one patients met the inclusion criteria. After an average follow-up of 1.2 years, 31 (38.3%) were dry, 25 (30.9%) had experienced significant improvement, 19 (23.5%) had experienced slight improvement, and 6 (7.4%) were unchanged. No significant differences were detected between those who became dry and those with little to no improvement with respect to age, sex, duration of symptoms, follow-up, uroflow pattern, postvoid residual urine volume, or bladder capacity. Those children presenting with decreased frequency of wetting episodes were significantly more likely to obtain daytime continence. The most common side effects were constipation (18.5%), dry mouth (17.3%), and flushing (13.6%). Conclusions: Children with daytime incontinence presenting with the lowest frequency of wetting were most likely to achieve continence. The frequency of wetting should be considered a significant prognostic variable when assessing the results of therapeutic intervention trials.

AB - Objectives: To examine the variables relative to the response of oxybutynin treatment in children with daytime urinary incontinence. Methods: The records of patients seen for voiding problems between 1999 and 2003 were reviewed. Patients taking oxybutynin for 3 months or longer were included in the study. Patients with structural or neurologic bladder abnormalities and those taking oxybutynin at the initial visit were excluded. Age, sex, uroflowmetry findings, postvoid residual urine volume, duration and severity of symptoms before oxybutynin, urinary tract infection history, constipation, and the duration, dosage, and adverse effects of oxybutynin treatment were evaluated. Data were analyzed using Fisher's exact test for categorical variables, the two-sample t test or Wilcoxon rank-sum test for continuous and ordinal variables, and the linear mixed model analysis for uroflow data. Results: Eighty-one patients met the inclusion criteria. After an average follow-up of 1.2 years, 31 (38.3%) were dry, 25 (30.9%) had experienced significant improvement, 19 (23.5%) had experienced slight improvement, and 6 (7.4%) were unchanged. No significant differences were detected between those who became dry and those with little to no improvement with respect to age, sex, duration of symptoms, follow-up, uroflow pattern, postvoid residual urine volume, or bladder capacity. Those children presenting with decreased frequency of wetting episodes were significantly more likely to obtain daytime continence. The most common side effects were constipation (18.5%), dry mouth (17.3%), and flushing (13.6%). Conclusions: Children with daytime incontinence presenting with the lowest frequency of wetting were most likely to achieve continence. The frequency of wetting should be considered a significant prognostic variable when assessing the results of therapeutic intervention trials.

UR - http://www.scopus.com/inward/record.url?scp=33646826117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646826117&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2005.11.060

DO - 10.1016/j.urology.2005.11.060

M3 - Article

C2 - 16698366

AN - SCOPUS:33646826117

VL - 67

SP - 1049

EP - 1053

JO - Urology

JF - Urology

SN - 0090-4295

IS - 5

ER -