Forces on adhesive contacts affect cell function

Catherine G. Galbraith, Michael P. Sheetz

Research output: Contribution to journalArticle

234 Scopus citations

Abstract

Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.

Original languageEnglish (US)
Pages (from-to)566-571
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume10
Issue number5
DOIs
StatePublished - Oct 1998

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Forces on adhesive contacts affect cell function'. Together they form a unique fingerprint.

  • Cite this