Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep

Juulia Lantto, Tiina Erkinaro, Mervi Haapsamo, Heikki Huhta, Hanna Marja Voipio, Alan (Roger) Hohimer, Lowell Davis, Ganesh Acharya, Juha Rasanen

Research output: Contribution to journalArticle

Abstract

New Findings: What is the central question of this study? At near-term gestation, foramen ovale blood flow accounts for a significant proportion of fetal left ventricular output. Can the foramen ovale increase its volume blood flow when right ventricular afterload is increased by main pulmonary artery occlusion? What is the main finding and its importance? Foramen ovale volume blood flow increased during main pulmonary artery occlusion. However, this increase was attributable to an increase in fetal heart rate, because left ventricular stroke volume remained unchanged. These findings suggest that the foramen ovale has a limited capacity to increase its volume blood flow. Abstract: The foramen ovale (FO) accounts for the majority of fetal left ventricular (LV) output. Increased right ventricular afterload can cause a redistribution of combined cardiac output between the ventricles. To understand the capability of the FO to increase its volume blood flow and thus LV output, we mechanically occluded the main pulmonary artery in seven chronically instrumented near-term sheep fetuses. We hypothesized that FO volume blood flow and LV output would increase during main pulmonary artery occlusion. Fetal cardiac function and haemodynamics were assessed by pulsed and tissue Doppler at baseline, 15 and 60 min after occlusion of the main pulmonary artery and 15 min after occlusion was released. Fetal ascending aorta and central venous pressures and blood gas values were monitored. Main pulmonary artery occlusion initially increased fetal heart rate (P < 0.05) from [mean (SD)] 158 (7) to 188 (23) beats min−1 and LV cardiac output (P < 0.0001) from 629 (198) to 776 (283) ml min−1. Combined cardiac output fell (P < 0.0001) from 1524 (341) to 720 (273) ml min−1. During main pulmonary artery occlusion, FO volume blood flow increased (P < 0.001) from 507 (181) to 776 (283) ml min−1. This increase was related to fetal tachycardia, because LV stroke volume did not change. Fetal ascending aortic blood pressure remained stable. Central venous pressure was higher (P < 0.05) during the occlusion than after it was released. During the occlusion, fetal pH decreased and PCO2 increased. Left ventricular systolic dysfunction developed while LV diastolic function was preserved. Right ventricular systolic and diastolic function deteriorated after the occlusion. In conclusion, the FO has a limited capacity to increase its volume blood flow at near-term gestation.

Original languageEnglish (US)
Pages (from-to)189-198
Number of pages10
JournalExperimental Physiology
Volume104
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Foramen Ovale
Pulmonary Artery
Sheep
Blood Volume
Cardiac Output
Fetal Heart Rate
Central Venous Pressure
Stroke Volume
Pregnancy
Left Ventricular Dysfunction
Left Ventricular Function
Tachycardia
Aorta
Arterial Pressure
Fetus
Gases
Hemodynamics

Keywords

  • blood flow
  • echocardiography
  • physiology

ASJC Scopus subject areas

  • Physiology

Cite this

Lantto, J., Erkinaro, T., Haapsamo, M., Huhta, H., Voipio, H. M., Hohimer, A. R., ... Rasanen, J. (2019). Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep. Experimental Physiology, 104(2), 189-198. https://doi.org/10.1113/EP087423

Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep. / Lantto, Juulia; Erkinaro, Tiina; Haapsamo, Mervi; Huhta, Heikki; Voipio, Hanna Marja; Hohimer, Alan (Roger); Davis, Lowell; Acharya, Ganesh; Rasanen, Juha.

In: Experimental Physiology, Vol. 104, No. 2, 01.02.2019, p. 189-198.

Research output: Contribution to journalArticle

Lantto, J, Erkinaro, T, Haapsamo, M, Huhta, H, Voipio, HM, Hohimer, AR, Davis, L, Acharya, G & Rasanen, J 2019, 'Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep', Experimental Physiology, vol. 104, no. 2, pp. 189-198. https://doi.org/10.1113/EP087423
Lantto J, Erkinaro T, Haapsamo M, Huhta H, Voipio HM, Hohimer AR et al. Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep. Experimental Physiology. 2019 Feb 1;104(2):189-198. https://doi.org/10.1113/EP087423
Lantto, Juulia ; Erkinaro, Tiina ; Haapsamo, Mervi ; Huhta, Heikki ; Voipio, Hanna Marja ; Hohimer, Alan (Roger) ; Davis, Lowell ; Acharya, Ganesh ; Rasanen, Juha. / Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep. In: Experimental Physiology. 2019 ; Vol. 104, No. 2. pp. 189-198.
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