Folate intake and prostate cancer risk: A case-control study

Jackilen (Jackie) Shannon, Elena Phoutrides, Amy Palma, Paige Farris, Laura Peters, Anna Forester, Carrie J. Tillotson, Mark Garzotto

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Folate deficiency has been implicated in the carcinogenesis of several tumor types. The role of folate in prostate cancer remains indeterminate. We investigated folate as a risk factor for prostate cancer among 140 biopsy-confirmed prostate cancer patients, 230 age-matched clinic controls, and 250 negative prostate biopsy controls. Dietary folate intake was inversely associated with overall risk of prostate cancer as compared to clinic controls (P for a linear trend = 0.003). When stratified by disease severity, dietary folate and folate from natural sources were associated with reduced risk of high-grade cancer as compared to both clinic controls (P for a linear trend = 0.0009 and 0.02, respectively) and biopsy negative controls (P for a linear trend = 0.03 and 0.05, respectively). There was no interaction between alcohol consumption and folate intake. These analyses support an inverse association between dietary folate intake and prostate cancer risk and primarily risk of high-grade prostate cancer.

Original languageEnglish (US)
Pages (from-to)617-628
Number of pages12
JournalNutrition and Cancer
Volume61
Issue number5
DOIs
Publication statusPublished - Sep 2009

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Shannon, J. J., Phoutrides, E., Palma, A., Farris, P., Peters, L., Forester, A., ... Garzotto, M. (2009). Folate intake and prostate cancer risk: A case-control study. Nutrition and Cancer, 61(5), 617-628. https://doi.org/10.1080/01635580902846593