Focal electrical stimulation of cortical functional networks

Jia Ming Hu, Mei Zhen Qian, Hisashi Tanigawa, Xue Mei Song, Anna Wang Roe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Traditional electrical stimulation of brain tissue typically affects relatively large volumes of tissue spanning multiple millimeters. This low spatial resolution stimulation results in nonspecific functional effects. In addition, a primary shortcoming of these designs was the failure to take advantage of inherent functional organization in the cerebral cortex. Here, we describe a new method to electrically stimulate the brain which achieves selective targeting of single feature-specific domains in visual cortex. We provide evidence that this paradigm achieves mesoscale, functional network-specificity, and intensity dependence in a way that mimics visual stimulation. Application of this approach to known feature domains (such as color, orientation, motion, and depth) in visual cortex may lead to important functional improvements in the specificity and sophistication of brain stimulation methods and has implications for visual cortical prosthetic design.

Original languageEnglish (US)
Pages (from-to)5532-5543
Number of pages12
JournalCerebral Cortex
Volume30
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • Brain-machine interface
  • Electrical microstimulation
  • Optical imaging
  • Orientation map
  • Visual cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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