Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography

Yimin Wang, Amani A. Fawzi, Ou Tan, Xinbo Zhang, David Huang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We used Doppler Fourier-domain optical coherence tomography (OCT) to investigate flicker-induced changes of total retinal blood flow. Total retinal blood flow was measured by summing flows in veins imaged in double-circular scans around the optic disc. In 3 healthy volunteers, total retinal blood flow was measured before and 10-15 seconds after 30 seconds of flicker stimulation. The average blood flow increased 22.2% (p = 0.002). The total venous and arterial vessel cross-sectional area increased 11.3% (p <0.001) and +2.7% (p = 0.28) respectively. The average venous and arterial flow velocity were calculated indirectly by dividing total retinal blood flow by total venous and arterial cross-sectional areas. They also increased by 8.8% (p = 0.046) and 18.3% (p = 0.004), respectively. These results show that human retinal blood flow increases after visible flicker stimulation, and this could be measured with OCT.

Original languageEnglish (US)
Pages (from-to)1852-1860
Number of pages9
JournalBiomedical Optics Express
Volume2
Issue number7
DOIs
StatePublished - 2011

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flicker
Optical Coherence Tomography
blood flow
tomography
stimulation
Optic Disk
veins
vessels
Veins
Healthy Volunteers
flow velocity
optics

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography. / Wang, Yimin; Fawzi, Amani A.; Tan, Ou; Zhang, Xinbo; Huang, David.

In: Biomedical Optics Express, Vol. 2, No. 7, 2011, p. 1852-1860.

Research output: Contribution to journalArticle

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